The Angiotensin I–Converting Enzyme Gene Insertion/Deletion Polymorphism Is Linked to Early Gastric Cancer

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 14; no. 12; pp. 2987 - 2989
• Main Authors: EBERT, Matthias P. A, LENDECKEL, Uwe, WESTPHAL, Sabine, DIERKES, Jutta, GLAS, Jiirgen, FOLWACZNY, Christian, ROESSNER, Albert, STOLTE, Manfred, MALFERTHEINER, Peter, RÖCKEN, Christoph
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.12.2005
• Subjects: Adult; Aged; Aged, 80 and over; angiotensin; Biological and medical sciences; Case-Control Studies; Chi-Square Distribution; early cancer; Female; gastric; Gastroenterology. Liver. Pancreas. Abdomen; Genotype; Helicobacter pylori; Humans; Male; Medical sciences; Middle Aged; Peptidyl-Dipeptidase A - genetics; Polymerase Chain Reaction; polymorphism; Polymorphism, Genetic; stomach; Stomach Neoplasms - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Human; Genetic variability; Enzyme; Insertion; Genotype; Malignant tumor; Stomach cancer; Carcinogenesis; Peptidases; Cancerology; Gene; Peptidyl-dipeptidase A; Deletion; Digestive diseases; Genetics; Hydrolases; Peptidyl-dipeptidases; Early; Gastric disease; Polymorphism
• ISSN: 1055-9965; 1538-7755
• DOI: 10.1158/1055-9965.EPI-05-0411

The insertion/deletion polymorphism of the angiotensin I–converting enzyme ( ACE ) gene has recently been linked to the pathogenesis and progression of human cancers. Using genomic DNA from 88 patients with early gastric cancer confined either to mucosa (pT 1a ) or submucosa (pT 1b ), we assessed the insertion (I) and deletion (D) polymorphism by PCR analysis and compared it with a large noncancer control population ( n = 145). In the noncancer control group, the II genotype was observed in 33 (23%) individuals, whereas the ID and DD genotypes were found in 72 (50%) and 40 (27%) individuals, respectively. Interestingly, in the cancer group, we found the II genotype in six (7%) patients and the ID genotype in 46 (52%) individuals, whereas the DD genotype was observed in 36 (41%) individuals ( P = 0.0034). Accordingly, the odds ratio for the II genotype was 0.20 [95% confidence interval (95% CI), 0.08-0.54; P = 0.009] and 0.55 for the ID/II genotype (95% CI, 0.31-0.96; P = 0.044) using the high-activity genotype DD as the reference category. No correlation was found among tumor type, tumor stage, the presence of Helicobacter pylori , and the ACE genotype. Our study provides further evidence that the ACE insertion/deletion gene polymorphism may be linked to the development of early gastric cancer. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2987–9)