Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications

We present giant magnetoresistance (GMR) spin valve sensors designed for detection of superparamagnetic nanoparticles as potential biomolecular labels in magnetic biodetection technology. We discuss the sensor design and experimentally demonstrate that as few as ∼23 monodisperse 16-nm superparamagne...

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Bibliographic Details
Published inSensors and actuators. A. Physical. Vol. 126; no. 1; pp. 98 - 106
Main Authors Li, Guanxiong, Sun, Shouheng, Wilson, Robert J., White, Robert L., Pourmand, Nader, Wang, Shan X.
Format Journal Article
LanguageEnglish
Published Switzerland Elsevier B.V 01.01.2006
Subjects
Actuators
Biodetection
Biosensor
Giant magnetoresistance
GMR
Labels
Lithography
Magnetic nanoparticle
Nanoparticles
Self assembly
Sensors
Spin valve sensor
Spin valves
Magnetic nanoparticle
Biodetection
GMR
Biosensor
Spin valve sensor
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Summary:We present giant magnetoresistance (GMR) spin valve sensors designed for detection of superparamagnetic nanoparticles as potential biomolecular labels in magnetic biodetection technology. We discuss the sensor design and experimentally demonstrate that as few as ∼23 monodisperse 16-nm superparamagnetic Fe 3O 4 nanoparticles can be detected by submicron spin valve sensors at room temperature without resorting to lock-in detection. A patterned self-assembly method of nanoparticles, based on a polymer-mediated process and fine lithography, is developed for the detection. It is found that sensor signal increases linearly with the number of nanoparticles.
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ISSN:0924-4247
1873-3069
DOI:10.1016/j.sna.2005.10.001