Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Microfluidic separation technology has garnered significant attention over the past decade where particles are being separated at a micro/nanoscale in a rapid, low-cost, and simple manner. Amongst a myriad of separation technologies that have emerged thus far, acoustic microfluidic separation techni...

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Published inMicromachines (Basel) Vol. 11; no. 10; p. 921
Main Authors Gao, Yuan, Wu, Mengren, Lin, Yang, Xu, Jie
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 02.10.2020
MDPI
Subjects
acoustic separation techniques
BAW
bioapplications
Biocompatibility
Biological properties
Blood cells
Bubbles
Commercialization
Controllability
Deoxyribonucleic acid
Dielectric properties
DNA
Microfluidics
Radiation
Review
Reynolds number
SAW
Saws
Separation
Sex crimes
Surface acoustic waves
Viscosity
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Summary:Microfluidic separation technology has garnered significant attention over the past decade where particles are being separated at a micro/nanoscale in a rapid, low-cost, and simple manner. Amongst a myriad of separation technologies that have emerged thus far, acoustic microfluidic separation techniques are extremely apt to applications involving biological samples attributed to various advantages, including high controllability, biocompatibility, and non-invasive, label-free features. With that being said, downsides such as low throughput and dependence on external equipment still impede successful commercialization from laboratory-based prototypes. Here, we present a comprehensive review of recent advances in acoustic microfluidic separation techniques, along with exemplary applications. Specifically, an inclusive overview of fundamental theory and background is presented, then two sets of mechanisms underlying acoustic separation, bulk acoustic wave and surface acoustic wave, are introduced and discussed. Upon these summaries, we present a variety of applications based on acoustic separation. The primary focus is given to those associated with biological samples such as blood cells, cancer cells, proteins, bacteria, viruses, and DNA/RNA. Finally, we highlight the benefits and challenges behind burgeoning developments in the field and discuss the future perspectives and an outlook towards robust, integrated, and commercialized devices based on acoustic microfluidic separation.
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ISSN:2072-666X
2072-666X
DOI:10.3390/mi11100921