Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

• Published in: Advanced materials (Weinheim) Vol. 24; no. 25; pp. 3362 - 3366
• Main Authors: Tan, Justin, Wang, Yajun, Yip, Xiaopei, Glynn, Fergal, Shepherd, Robert K., Caruso, Frank
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 03.07.2012; WILEY‐VCH Verlag
• Subjects: Animals; Apoptosis - drug effects; Brain-Derived Neurotrophic Factor - administration & dosage; Brain-Derived Neurotrophic Factor - chemistry; Brain-Derived Neurotrophic Factor - pharmacology; Cell Line, Tumor; Cochlea - metabolism; Disease Models, Animal; Drug Carriers - chemistry; drug delivery; Guinea Pigs; Hearing Loss, Sensorineural - chemically induced; Hearing Loss, Sensorineural - drug therapy; Humans; mesoporous silica; Nanoparticles - chemistry; nanoporous polymer particles; neurotrophic factors; Peptides - chemistry; Porosity; sensorineural hearing loss

Neurotrophin‐BDNF can be effectively encapsulated in nanoporous poly(L‐glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue...