Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

Neurotrophin‐BDNF can be effectively encapsulated in nanoporous poly(L‐glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 24; no. 25; pp. 3362 - 3366
Main Authors Tan, Justin, Wang, Yajun, Yip, Xiaopei, Glynn, Fergal, Shepherd, Robert K., Caruso, Frank
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 03.07.2012
WILEY‐VCH Verlag
Subjects
Animals
Apoptosis - drug effects
Brain-Derived Neurotrophic Factor - administration & dosage
Brain-Derived Neurotrophic Factor - chemistry
Brain-Derived Neurotrophic Factor - pharmacology
Cell Line, Tumor
Cochlea - metabolism
Disease Models, Animal
Drug Carriers - chemistry
drug delivery
Guinea Pigs
Hearing Loss, Sensorineural - chemically induced
Hearing Loss, Sensorineural - drug therapy
Humans
mesoporous silica
Nanoparticles - chemistry
nanoporous polymer particles
neurotrophic factors
Peptides - chemistry
Porosity
sensorineural hearing loss
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Summary:Neurotrophin‐BDNF can be effectively encapsulated in nanoporous poly(L‐glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.
Bibliography:istex:6E8528585892DFEA5A63C75196CC94697FBC3F43
ark:/67375/WNG-SRDRQJSC-V
ArticleID:ADMA201200634
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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J. Tan and Y. Wang contributed equally.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201200634