Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

Neurotrophin‐BDNF can be effectively encapsulated in nanoporous poly(L‐glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue...

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Published in	Advanced materials (Weinheim) Vol. 24; no. 25; pp. 3362 - 3366
Main Authors	Tan, Justin, Wang, Yajun, Yip, Xiaopei, Glynn, Fergal, Shepherd, Robert K., Caruso, Frank
Format	Journal Article
Language	English
Published	Weinheim WILEY-VCH Verlag 03.07.2012 WILEY‐VCH Verlag
Subjects	Animals Apoptosis - drug effects Brain-Derived Neurotrophic Factor - administration & dosage Brain-Derived Neurotrophic Factor - chemistry Brain-Derived Neurotrophic Factor - pharmacology Cell Line, Tumor Cochlea - metabolism Disease Models, Animal Drug Carriers - chemistry drug delivery Guinea Pigs Hearing Loss, Sensorineural - chemically induced Hearing Loss, Sensorineural - drug therapy Humans mesoporous silica Nanoparticles - chemistry nanoporous polymer particles neurotrophic factors Peptides - chemistry Porosity sensorineural hearing loss
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Abstract	Neurotrophin‐BDNF can be effectively encapsulated in nanoporous poly(L‐glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.
AbstractList	Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss. Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with maintained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss. Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.
Author	Tan, Justin Wang, Yajun Shepherd, Robert K. Glynn, Fergal Caruso, Frank Yip, Xiaopei
Author_xml	– sequence: 1 givenname: Justin surname: Tan fullname: Tan, Justin organization: Bionics Institute, East Melbourne, Victoria 3002, Australia – sequence: 2 givenname: Yajun surname: Wang fullname: Wang, Yajun organization: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia – sequence: 3 givenname: Xiaopei surname: Yip fullname: Yip, Xiaopei organization: Bionics Institute, East Melbourne, Victoria 3002, Australia – sequence: 4 givenname: Fergal surname: Glynn fullname: Glynn, Fergal organization: Bionics Institute, East Melbourne, Victoria 3002, Australia – sequence: 5 givenname: Robert K. surname: Shepherd fullname: Shepherd, Robert K. organization: Bionics Institute, East Melbourne, Victoria 3002, Australia – sequence: 6 givenname: Frank surname: Caruso fullname: Caruso, Frank email: fcaruso@unimelb.edu.au organization: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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Snippet	Neurotrophin‐BDNF can be effectively encapsulated in nanoporous poly(L‐glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can... Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can...
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SubjectTerms	Animals Apoptosis - drug effects Brain-Derived Neurotrophic Factor - administration & dosage Brain-Derived Neurotrophic Factor - chemistry Brain-Derived Neurotrophic Factor - pharmacology Cell Line, Tumor Cochlea - metabolism Disease Models, Animal Drug Carriers - chemistry drug delivery Guinea Pigs Hearing Loss, Sensorineural - chemically induced Hearing Loss, Sensorineural - drug therapy Humans mesoporous silica Nanoparticles - chemistry nanoporous polymer particles neurotrophic factors Peptides - chemistry Porosity sensorineural hearing loss
Title	Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration
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