Multicomponent Synthesis of Unsymmetrical Unsaturated N-Heterocyclic Carbene Precursors and Their Related Transition-Metal Complexes

• Published in: Angewandte Chemie (International ed.) Vol. 52; no. 52; pp. 14103 - 14107
• Main Authors: Queval, Pierre, Jahier, Claire, Rouen, Mathieu, Artur, Isabelle, Legeay, Jean-Christophe, Falivene, Laura, Toupet, Loic, Crévisy, Christophe, Cavallo, Luigi, Baslé, Olivier, Mauduit, Marc
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 23.12.2013; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc; Wiley-VCH Verlag
• Edition: International ed. in English
• Subjects: Carbenes; Chemical bonds; Chemical Sciences; Chemistry; Chemistry, Multidisciplinary; chirality; Demand; Discrimination; Electronics; ligand design; Ligands; Modular; multicomponent reactions; N-heterocyclic carbenes; Other; Physical Sciences; R&D; Research & development; Science & Technology; Selectivity; transition metals; Unsaturated; multicomponent reactions; chirality; LIGANDS; transition metals; ligand design; ALKYL AMINO CARBENES; RESTRICTED FLEXIBILITY; METATHESIS; CATALYSTS; N-heterocyclic carbenes; transition metal complex cycloalkyl imidazolidene carbene prepn crystal structure; aryl cycloalkyl imidazolium salt prepn crystal mol structure reaction; unsym unsatd heterocyclic imidazolidene carbene precursor multicomponent synthesis

A low‐cost, modular, and easily scalable multicomponent procedure affording access in good yields and excellent selectivity (up to 93 %) to a wide range of (a)chiral unsymmetrical 1‐aryl‐3‐cycloalkyl‐imidazolium salts is disclosed. Electronic and steric properties of the corresponding unsymmetrical...