FUNGAL METABOLITES. PART 14†. NOVEL POTENT IMMUNOSUPPRESSANTS, MYCESTERICINS, PRODUCED BY Mycelia sterilia

• Published in: Journal of antibiotics Vol. 47; no. 4; pp. 420 - 433
• Main Authors: SASAKI, SHGEO, HASHIMOTO, RYOUTA, KIUCHI, MASATOSHI, INOUE, KENICHIRO, IKUMOTO, TAKESHI, HIROSE, RYOJI, CHIBA, KENJI, HOSHINO, YUKIO, OKUMOTO, TAKEKI, FUJITA, TETSURO
• Format: Journal Article
• Language: English
• Published: Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1994
• Subjects: Animals; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Cell Division - drug effects; Chromatography, High Pressure Liquid; Eicosanoic Acids - chemistry; Eicosanoic Acids - isolation & purification; Eicosanoic Acids - pharmacology; Fatty Acids, Monounsaturated - chemistry; Fatty Acids, Monounsaturated - isolation & purification; Fatty Acids, Monounsaturated - pharmacology; Fatty Acids, Unsaturated - biosynthesis; Fatty Acids, Unsaturated - chemistry; Fatty Acids, Unsaturated - isolation & purification; Fatty Acids, Unsaturated - pharmacology; Immunosuppressive Agents - chemistry; Immunosuppressive Agents - isolation & purification; Immunosuppressive Agents - pharmacology; Lymphocyte Culture Test, Mixed; Lymphocytes - drug effects; Lymphocytes - immunology; Magnetic Resonance Spectroscopy; Mice; Mitosporic Fungi - metabolism; Mycelia sterilia; Stereoisomerism
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.47.420

Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (= myriocin). Their structures were elucidated on the basis of spectroscopic studies and chemical evidence. The acetate of mycestericin C was identical with the acetate of 6, 7-dihydromyriocin. Mycestericins suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction, with a potency similar to that of myriocin.