Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults
The age-related decrease in cerebral blood flow velocity increases the risk of cerebrovascular disease. Milk protein-derived bioactive peptides, e.g., lactotripeptide (LTP), have been shown to inhibit angiotensin converting enzyme activities and increase vasodilator production. We hypothesized that...
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| Published in | Nutrition research (New York, N.Y.) Vol. 53; pp. 61 - 66 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.05.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0271-5317 1879-0739 1879-0739 |
| DOI | 10.1016/j.nutres.2018.03.009 |
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| Abstract | The age-related decrease in cerebral blood flow velocity increases the risk of cerebrovascular disease. Milk protein-derived bioactive peptides, e.g., lactotripeptide (LTP), have been shown to inhibit angiotensin converting enzyme activities and increase vasodilator production. We hypothesized that LTP ingestion increases cerebral blood flow velocity in middle-aged and older adults. In a randomized, placebo-controlled, double-blind design, 15 healthy middle-aged and older adults were assigned to either a LTP group or a placebo group. The subjects ingested LTP or placebo orally for 8 weeks. Before and after intervention, middle cerebral blood flow velocity was measured using transcranial Doppler ultrasonography. The baseline middle cerebral blood flow velocity and most other key dependent variables did not differ between the groups. LTP ingestion significantly increased middle cerebral blood flow velocity, but there was no such improvement in the placebo groups. We concluded that 8 weeks of LTP ingestion increased middle cerebral blood flow velocity in middle-aged and older adults. |
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| AbstractList | The age-related decrease in cerebral blood flow velocity increases the risk of cerebrovascular disease. Milk protein-derived bioactive peptides, e.g., lactotripeptide (LTP), have been shown to inhibit angiotensin converting enzyme activities and increase vasodilator production. We hypothesized that LTP ingestion increases cerebral blood flow velocity in middle-aged and older adults. In a randomized, placebo-controlled, double-blind design, 15 healthy middle-aged and older adults were assigned to either a LTP group or a placebo group. The subjects ingested LTP or placebo orally for 8 weeks. Before and after intervention, middle cerebral blood flow velocity was measured using transcranial Doppler ultrasonography. The baseline middle cerebral blood flow velocity and most other key dependent variables did not differ between the groups. LTP ingestion significantly increased middle cerebral blood flow velocity, but there was no such improvement in the placebo groups. We concluded that 8 weeks of LTP ingestion increased middle cerebral blood flow velocity in middle-aged and older adults.The age-related decrease in cerebral blood flow velocity increases the risk of cerebrovascular disease. Milk protein-derived bioactive peptides, e.g., lactotripeptide (LTP), have been shown to inhibit angiotensin converting enzyme activities and increase vasodilator production. We hypothesized that LTP ingestion increases cerebral blood flow velocity in middle-aged and older adults. In a randomized, placebo-controlled, double-blind design, 15 healthy middle-aged and older adults were assigned to either a LTP group or a placebo group. The subjects ingested LTP or placebo orally for 8 weeks. Before and after intervention, middle cerebral blood flow velocity was measured using transcranial Doppler ultrasonography. The baseline middle cerebral blood flow velocity and most other key dependent variables did not differ between the groups. LTP ingestion significantly increased middle cerebral blood flow velocity, but there was no such improvement in the placebo groups. We concluded that 8 weeks of LTP ingestion increased middle cerebral blood flow velocity in middle-aged and older adults. The age-related decrease in cerebral blood flow velocity increases the risk of cerebrovascular disease. Milk protein-derived bioactive peptides, e.g., lactotripeptide (LTP), have been shown to inhibit angiotensin converting enzyme activities and increase vasodilator production. We hypothesized that LTP ingestion increases cerebral blood flow velocity in middle-aged and older adults. In a randomized, placebo-controlled, double-blind design, 15 healthy middle-aged and older adults were assigned to either a LTP group or a placebo group. The subjects ingested LTP or placebo orally for 8 weeks. Before and after intervention, middle cerebral blood flow velocity was measured using transcranial Doppler ultrasonography. The baseline middle cerebral blood flow velocity and most other key dependent variables did not differ between the groups. LTP ingestion significantly increased middle cerebral blood flow velocity, but there was no such improvement in the placebo groups. We concluded that 8 weeks of LTP ingestion increased middle cerebral blood flow velocity in middle-aged and older adults. |
| Author | Hamasaki, Ai Kosaki, Keisei Tanahashi, Koichiro Myoenzono, Kanae Akazawa, Nobuhiko Yoshikawa, Toru Maeda, Seiji |
| Author_xml | – sequence: 1 givenname: Nobuhiko surname: Akazawa fullname: Akazawa, Nobuhiko organization: Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan – sequence: 2 givenname: Ai surname: Hamasaki fullname: Hamasaki, Ai organization: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan – sequence: 3 givenname: Koichiro surname: Tanahashi fullname: Tanahashi, Koichiro organization: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan – sequence: 4 givenname: Keisei surname: Kosaki fullname: Kosaki, Keisei organization: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan – sequence: 5 givenname: Toru surname: Yoshikawa fullname: Yoshikawa, Toru organization: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan – sequence: 6 givenname: Kanae surname: Myoenzono fullname: Myoenzono, Kanae organization: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan – sequence: 7 givenname: Seiji surname: Maeda fullname: Maeda, Seiji email: maeda.seiji.gn@u.tsukuba.ac.jp organization: Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29703414$$D View this record in MEDLINE/PubMed |
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| Keywords | PETCO2 Executive function ACE CO2 VPP IPP Aging LTP Milk peptides Casein hydrolysate Cerebral hemodynamics |
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| Title | Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults |
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