Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults

• Published in: Nutrition research (New York, N.Y.) Vol. 53; pp. 61 - 66
• Main Authors: Akazawa, Nobuhiko, Hamasaki, Ai, Tanahashi, Koichiro, Kosaki, Keisei, Yoshikawa, Toru, Myoenzono, Kanae, Maeda, Seiji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2018
• Subjects: Aged; Aging; blood flow; Blood Flow Velocity - drug effects; Casein hydrolysate; Cerebral hemodynamics; Cerebrovascular Circulation - drug effects; cerebrovascular disorders; Double-Blind Method; elderly; enzyme activity; Executive function; Female; Humans; Male; Middle Aged; Middle Cerebral Artery - drug effects; Middle Cerebral Artery - physiology; middle-aged adults; milk; Milk peptides; Milk Proteins - chemistry; nutrition risk assessment; peptides; Peptides - pharmacology; Peptides - therapeutic use; peptidyl-dipeptidase A; placebos; ultrasonography; Ultrasonography, Doppler, Transcranial; PETCO2; Executive function; ACE; CO2; VPP; IPP; Aging; LTP; Milk peptides; Casein hydrolysate; Cerebral hemodynamics
• ISSN: 0271-5317; 1879-0739; 1879-0739
• DOI: 10.1016/j.nutres.2018.03.009

The age-related decrease in cerebral blood flow velocity increases the risk of cerebrovascular disease. Milk protein-derived bioactive peptides, e.g., lactotripeptide (LTP), have been shown to inhibit angiotensin converting enzyme activities and increase vasodilator production. We hypothesized that LTP ingestion increases cerebral blood flow velocity in middle-aged and older adults. In a randomized, placebo-controlled, double-blind design, 15 healthy middle-aged and older adults were assigned to either a LTP group or a placebo group. The subjects ingested LTP or placebo orally for 8 weeks. Before and after intervention, middle cerebral blood flow velocity was measured using transcranial Doppler ultrasonography. The baseline middle cerebral blood flow velocity and most other key dependent variables did not differ between the groups. LTP ingestion significantly increased middle cerebral blood flow velocity, but there was no such improvement in the placebo groups. We concluded that 8 weeks of LTP ingestion increased middle cerebral blood flow velocity in middle-aged and older adults.