Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR-γ/HO-1 pathways

• Published in: Molecular medicine reports Vol. 14; no. 6; pp. 5528 - 5534
• Main Authors: Shen, Xiaohua, Wang, Meihui, Bi, Xukun, Zhang, Jiefang, Wen, Shaoxiang, Fu, Guosheng, Xia, Liang
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Acids; Adult; Aging; Animals; Antioxidants - pharmacology; Biotechnology; Cardiovascular disease; Cardiovascular system; Cells; Cells, Cultured; Cellular Senescence; Cellular signal transduction; Coronary vessels; Diabetes; endothelial progenitor cell; Endothelial Progenitor Cells - drug effects; Endothelial Progenitor Cells - metabolism; Endothelium; Female; Gene Expression; Growth factors; Health aspects; Heme; Heme oxygenase (decyclizing); Heme Oxygenase-1 - metabolism; Humans; Hyperplasia; Ischemia; Kinases; Laboratories; Male; Myocardial ischemia; Nitric Oxide - metabolism; oxidative reaction; Oxidative stress; Oxidative Stress - drug effects; Oxygenase; Peroxisome proliferator-activated receptors; Potassium; PPAR gamma - metabolism; Proteins; Rabbits; Reactive Oxygen Species - metabolism; Reperfusion; Resveratrol; Rodents; Senescence; Signal Transduction - drug effects; Stem cells; Stilbenes - pharmacology; Telomerase; Telomerase - genetics; Telomerase - metabolism; Vascularization; United States > US
• ISSN: 1791-2997; 1791-3004
• DOI: 10.3892/mmr.2016.5929

Increasing evidence suggests endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Resveratrol (RSV) is a natural polyphenolic compound, which has been demonstrated to exert multiple protective effects on the cardiovascular system, including inhibition of platelet adhesion and aggregation, reduction of myocardial ischemia-reperfusion injury, and suppression of neointimal hyperplasia of injured vascular tissue. The present study investigated the role of RSV on levels of oxidative stress and senescence of EPCs, and the effects of RSV on vascular-promoting and/or vascular-healing capacity of EPCs. It was demonstrated that EPCs could promote the repair of endothelium of the injured artery. RSV reduced the oxidative reaction of EPCs and inhibited EPC senescence, and these effects may occur via the peroxisome proliferator-activated receptor-γ/heme oxygenase-1 signaling pathways.