Antibodies against Lutzomyia longipalpis saliva in the fox Cerdocyon thous and the sylvatic cycle of Leishmania chagasi
Sera of 11 wild Cerdocyon thous foxes from an endemic area for American visceral leishmaniasis were tested for the presence of antibodies against salivary gland homogenates (SGH) of Lutzomyia longipalpis. All foxes had higher levels of anti- Lu. longipalpis SGH antibodies than foxes from non-endemic...
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Published in | Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 101; no. 2; pp. 127 - 133 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.02.2007
Royal Society of Tropical Medicine and Hygiene Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Sera of 11 wild
Cerdocyon thous foxes from an endemic area for American visceral leishmaniasis were tested for the presence of antibodies against salivary gland homogenates (SGH) of
Lutzomyia longipalpis. All foxes had higher levels of anti-
Lu. longipalpis SGH antibodies than foxes from non-endemic areas, suggesting contact between foxes and the vector of visceral leishmaniasis. Sera of humans and dogs living in the same area were also tested for reactivity against
Lu. longipalpis SGHs and had a lower proportion of reactivity than foxes. Antibodies against
Leishmania chagasi were not detected in any of the foxes, but three foxes showed the presence of parasites in the bone marrow by direct examination, PCR or by infecting the vector. Both humans and dogs had higher levels of anti-
Le. chagasi IgG antibodies than
C. thous. The finding of an antibody response against saliva of
Lu. longipalpis among
C. thous together with the broad distribution of the vector in resting areas of infected foxes suggests that the natural foci of transmission of
Le. chagasi exists independently of the transmission among dogs and humans. |
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Bibliography: | The authors have no conflicts of interest concerning the work reported in this paper. ark:/67375/HXZ-W39LPPNV-C istex:8D845A5C6EB439231C59F78149A5A7E46EC78825 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0035-9203 1878-3503 |
DOI: | 10.1016/j.trstmh.2006.06.002 |