Supplying a Pharmacy for NASA Exploration Spaceflight: Challenges and Current Understanding
In order to maintain crew health and performance during long-duration spaceflight outside of low-Earth orbit, NASA and its international partners must be capable of providing a safe and effective pharmacy. Given few directed studies of pharmaceuticals in the space environment, it is difficult to cha...
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Published in | NPJ microgravity Vol. 5; no. 1; pp. 14 - 12 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Johnson Space Center
Nature Research
13.06.2019
Nature Publishing Group Nature Publishing Group UK |
Subjects | |
Online Access | Get full text |
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Summary: | In order to maintain crew health and performance during long-duration spaceflight outside of low-Earth orbit, NASA and its international partners must be capable of providing a safe and effective pharmacy. Given few directed studies of pharmaceuticals in the space environment, it is difficult to characterize pharmaceutical effectiveness or stability during spaceflight; this in turn makes it challenging to select an appropriate formulary for exploration. Here we present the current state of literature regarding pharmaceutical stability, metabolism, and effectiveness during spaceflight. In particular, we have attempted to highlight the gaps in current knowledge and the difficulties in translating terrestrial-based drug studies to a meaningful interpretation of drug stability, safety, and effectiveness in space. We hope to identify high-yield opportunities for future research that might better define and mitigate pharmaceutical risk for exploration missions. |
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Bibliography: | Johnson Space Center JSC-E-DAA-TN70241 JSC ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 2373-8065 2373-8065 |
DOI: | 10.1038/s41526-019-0075-2 |