Effects of Dietary Fat Sources during Late Gestation on Colostrum Quality and Mammary Gland Inflammation in Lipopolysaccharide-Challenged Sows

• Published in: Animals (Basel) Vol. 10; no. 2; p. 319
• Main Authors: Zou, Tiande, Wei, Wenzhuo, Cao, Shanchuan, Zhang, Hongfu, Liu, Jingbo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2020; MDPI
• Subjects: Analysis; Colostrum; Diagnosis; Dietary fat; Diseases; fat; inflammatory response; Influence; lipopolysaccharide; mammary gland; Mastitis; Nutritional aspects; Physiological aspects; Pregnancy; Sows; China; fat; inflammatory response; mammary gland; lipopolysaccharide; colostrum
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani10020319

This study aimed to investigate the effects of maternal lipopolysaccharide (LPS) challenge and dietary fat sources on colostrum quality and inflammatory response in sows. Sixty Landrace × Yorkshire sows were randomly assigned to three dietary treatments supplemented with 3% soybean oil (SO), 3% coconut oil (CO) or 3% fish oil (FO), respectively, from Day 90 of gestation until parturition. On Day 112 of gestation, half the sows from each dietary treatment were challenged with LPS (10 μg/kg BW) or saline. The results showed that maternal LPS challenge decreased colostrum yield and dry matter content. A similar pattern of changes was observed for body weight gain and colostrum intake in piglets from LPS-challenged sows. Maternal LPS challenge increased the levels of tumor necrosis factor α ( ), interleukin 1β ( ) and in colostum, and the mRNA abundance of , and and the phosphorylation level of in mammary glands. However, the responses of these variables to LPS treatment were lower in sows fed a FO diet. In conclusion, maternal immune challenge reduced the growth performance of piglets by decreasing colostrum yield and intake by piglets, and dietary supplementation with FO in sows attenuates the LPS-induced inflammatory response in mammary glands.