Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity

Covering: up to May 2010 This review (with 214 references cited) is devoted to moenomycins, the only known group of antibiotics that directly inhibit bacterial peptidoglycan glycosytransferases. Naturally occurring moenomycins and chemical and biological approaches to their derivatives are described...

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Bibliographic Details
Published inNatural product reports Vol. 27; no. 11; pp. 1594 - 1617
Main Authors Ostash, Bohdan, Walker, Suzanne
Format Journal Article
LanguageEnglish
Published England 01.01.2010
Subjects
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics
Disease Models, Animal
Glycosyltransferases - antagonists & inhibitors
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Mice
Microbial Sensitivity Tests
moenomycin
Molecular Structure
natural products
Oligosaccharides - biosynthesis
Oligosaccharides - chemical synthesis
Oligosaccharides - chemistry
Oligosaccharides - pharmacology
peptidoglycans
Streptomyces - chemistry
Streptomyces - metabolism
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Summary:Covering: up to May 2010 This review (with 214 references cited) is devoted to moenomycins, the only known group of antibiotics that directly inhibit bacterial peptidoglycan glycosytransferases. Naturally occurring moenomycins and chemical and biological approaches to their derivatives are described. The biological properties of moenomycins and plausible mechanisms of bacterial resistance to them are also covered here, portraying a complete picture of the chemistry and biology of these fascinating natural products. This review is devoted to moenomycins, the only known group of antibiotics that directly inhibit bacterial peptidoglycan glycosytransferases. Naturally occurring moenomycins and chemical and biological approaches to their derivatives are described, together with their biological properties and plausible mechanisms of bacterial resistance to them.
Bibliography:Bohdan Ostash was born and raised in the rural L'vivska region of the Ukraine. He studied biology and received a B.S. in biology from Ivan Franko National University of L'viv (IFNUL). Bohdan entered the graduate program in Genetics at IFNUL in 1999 and graduated from the Department of Genetics and Biotechnology in 2003 with a PhD centered on the examination of biosynthesis of angucycline polyketides with Professor Victor Fedorenko. Bohdan then completed his postdoctoral training with Professor Suzanne Walker in the Department of Microbiology and Molecular Genetics at Harvard Medical School. While at Harvard, he initiated genetic studies on phosphoglycolipid antibiotics produced by
He is currently a Senior Researcher in the Department of Genetics and Biotechnology of IFNUL. His recent research interests include the use of microbiological, genetic and bioinformatic tools to manipulate the microbial secondary metabolome.
Streptomyces ghanaensis
Professor Suzanne Walker spent her childhood on the Navajo Reservation near Chaco Canyon, New Mexico. She received a B.A. in English Literature from the University of Chicago and then attended Princeton University, where she received her Ph.D. in Organic Chemistry. She eventually joined the faculty at Princeton as a Professor of Chemistry. In 2004, she moved to the Department of Microbiology and Molecular Genetics at Harvard Medical School. Professor Walker started her independent career working on cell wall biosynthesis in bacteria, an area that continues to be a major focus. She currently studies metabolic pathways involved in microbial survival and pathogenesis. The underlying motivation for her projects is to develop the scientific foundations for the discovery and evaluation of new targets, strategies, and compounds to treat resistant bacterial infections.
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ISSN:0265-0568
1460-4752
DOI:10.1039/c001461n