A novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine
► α-1,6-Glucosaccharides promote quercetin glycoside absorption in the small intestine. ► The saccharides enhance water-solubility of quercetin glycoside in the intestine. ► The effects of megalo-size saccharide are higher than those of oligo-size saccharide. The presence of an α-1,6-glucosaccharide...
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Published in | Food chemistry Vol. 136; no. 2; pp. 293 - 296 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Ltd
15.01.2013
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | ► α-1,6-Glucosaccharides promote quercetin glycoside absorption in the small intestine. ► The saccharides enhance water-solubility of quercetin glycoside in the intestine. ► The effects of megalo-size saccharide are higher than those of oligo-size saccharide.
The presence of an α-1,6-glucosaccharide enhances absorption of water-soluble quercetin glycosides, a mixture of quercetin-3-O-β-d-glucoside (Q3G, 31.8%), mono (23.3%), di (20.3%) and more d-glucose adducts with α-1,4-linkage to a d-glucose moiety of Q3G, in a ligated small intestinal loop of anesthetized rats. We prepared α-1,6-glucosaccharides with different degrees of polymerization (DP) enzymatically and separated them into a megalo-isomaltosaccharide-containing fraction (M-IM, average DP=11.0) and an oligo-isomaltosaccharide-containing fraction (O-IM, average DP=3.6). Luminal injection of either saccharide fraction promoted the absorption of total quercetin-derivatives from the small intestinal segment and this effect was greater for M-IM than O-IM addition. M-IM also increased Q3G, but not the quercetin aglycone, concentration in the water-phase of the luminal contents more strongly than O-IM. The enhancement of Q3G solubilization in the luminal contents may be responsible for the increases in the quercetin glucoside absorption promoted by α-1,6-glucosaccharides, especially that by M-IM. These results suggest that the ingestion of α-1,6-glucosaccharides promotes Q3G bioavailability. |
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Bibliography: | http://dx.doi.org/10.1016/j.foodchem.2012.08.028 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0308-8146 1873-7072 |
DOI: | 10.1016/j.foodchem.2012.08.028 |