Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn

• Published in: Burns Vol. 41; no. 8; pp. 1775 - 1787
• Main Authors: Wang, Cheng Z, Ayadi, Amina El, Goswamy, Juhi, Finnerty, Celeste C, Mifflin, Randy, Sousse, Linda, Enkhbaatar, Perenlei, Papaconstantinou, John, Herndon, David N, Ansari, Naseem H
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2015
• Subjects: Acrolein - metabolism; Administration, Cutaneous; Aldehyde Dehydrogenase - drug effects; Aldehyde Dehydrogenase - metabolism; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes - metabolism; Animals; Brass comb burn; Burn progression; Burns; Chelating Agents - pharmacology; Copper; Critical Care; Dimethyl Sulfoxide - pharmacology; Disease Models, Animal; Edetic Acid - pharmacology; Immunohistochemistry; Iron chelation; Malondialdehyde - metabolism; Mitochondrial Proteins - drug effects; Mitochondrial Proteins - metabolism; Oxidative stress; Oxidative Stress - drug effects; Permeability - drug effects; Rats; Reactive aldehydes; Retinal Dehydrogenase - drug effects; Retinal Dehydrogenase - metabolism; Skin - drug effects; Skin - metabolism; Skin - pathology; Sulfones - pharmacology; Thermal injury; Trauma Severity Indices; Wound healing; Zinc; Brass comb burn; lipid aldehydes; livionex formulation; Iron chelation; Oxidative stress; Reactive aldehydes; Wound healing; aldehyde dehydrogenase; MSM; MDA; EDTA; 4-hydroxynonenal; Burn progression; ALDH; Thermal injury; LA; ROS; reactive oxygen species; ethylenediaminetetraacetic acid; methyl sulfonyl methane; LF; malonadialdehyde and acrolein (ACR); HNE
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/j.burns.2015.08.012

Highlights • We examine a novel strategy to ameliorate progression of full thickness burn. • The mechanism relies on the use of a metal chelator to control oxidative damage. • Involvement of toxic lipid aldehydes suggestive in burns. • Possible intervention of burns by topical application of metal chelator.