The Risk of Cancer Associated with Specific Mutations of BRCA1 and BRCA2 among Ashkenazi Jews

Current estimates of the risk of breast cancer in a woman who carries a BRCA1 or BRCA2 mutation and is from a kindred with multiple cases of breast or ovarian cancer, or both, range from 76 to 87 percent. 1 – 4 Estimates of the risk of ovarian cancer in a woman from such a kindred range from 32 to 8...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 336; no. 20; pp. 1401 - 1408
Main Authors Struewing, Jeffery P, Hartge, Patricia, Wacholder, Sholom, Baker, Sonya M, Berlin, Martha, McAdams, Mary, Timmerman, Michelle M, Brody, Lawrence C, Tucker, Margaret A
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 15.05.1997
Subjects
Adult
Aged
Aged, 80 and over
Analysis. Health state
Biological and medical sciences
BRCA2 Protein
Breast cancer
Breast Neoplasms - ethnology
Breast Neoplasms - genetics
Colonic Neoplasms - ethnology
Colonic Neoplasms - genetics
Confidence intervals
Deoxyribonucleic acid
DNA
Epidemiology
Families & family life
Female
General aspects
Genes, BRCA1
Germ-Line Mutation
Heterozygote
Humans
Incidence
Jewish people
Jews
Male
Medical sciences
Middle Aged
Mutation
Neoplasm Proteins - genetics
Neoplasms - ethnology
Neoplasms - genetics
Ovarian cancer
Ovarian Neoplasms - ethnology
Ovarian Neoplasms - genetics
Prostatic Neoplasms - ethnology
Prostatic Neoplasms - genetics
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk
Transcription Factors - genetics
Women
Human
Ethnic origin
Carcinoma
Malignant tumor
Epidemiology
Mammary gland diseases
Risk factor
Genetics
Female
Influence
Mammary gland
Mutation
Jew
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Summary:Current estimates of the risk of breast cancer in a woman who carries a BRCA1 or BRCA2 mutation and is from a kindred with multiple cases of breast or ovarian cancer, or both, range from 76 to 87 percent. 1 – 4 Estimates of the risk of ovarian cancer in a woman from such a kindred range from 32 to 84 percent for carriers of BRCA1 mutations but are much lower for carriers of BRCA2 mutations. 2 – 4 These results were derived from studies of high-risk families and may not apply to all carriers of BRCA1 or BRCA2 mutations. The large size of . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199705153362001