Morphofunctional study on the effects of passive smoking in kidneys of rats

OBJECTIVETo analyze whether passive inhalation of cigarette smoke causes morphological, structural, and functional changes in kidneys of rats. METHODSWistar rats, aged eight weeks, weighing on average 260g, were divided into Control Group and Smoking Group. Each group was subdivided into four groups...

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Bibliographic Details
Published inEinstein (São Paulo, Brazil) Vol. 19; p. eAO6000
Main Authors Moraes, Carlos Alberto de, Breda-Stella, Mercia, Carvalho, Cesar Alexandre Fabrega
Format Journal Article
LanguageEnglish
Portuguese
Published Instituto Israelita de Ensino e Pesquisa Albert Einstein 01.01.2021
Subjects
Diabetic nephropathies
Glomerular filtration rate
Kidney cortex
Kidney glomerulus
MEDICINE, GENERAL & INTERNAL
Mesangial cells
Original
Rats, Wistar
Tobacco smoke pollution
Nefropatias diabéticas
Rats, Wistar
Diabetic nephropathies
Taxa de filtração glomerular
Kidney glomerulus
Glomerular filtration rate
Glomérulos renais
Poluição por fumaça de tabaco
Córtex renal
Mesangial cells
Ratos Wistar
Tobacco smoke pollution
Células mesangiais
Kidney cortex
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Summary:OBJECTIVETo analyze whether passive inhalation of cigarette smoke causes morphological, structural, and functional changes in kidneys of rats. METHODSWistar rats, aged eight weeks, weighing on average 260g, were divided into Control Group and Smoking Group. Each group was subdivided into four groups of ten animals for morphofunctional analysis, in a period of seven and 28 days. The Smoking Group was exposed to smoke of 40 cigarettes per day, at certain times and in automated equipment for cigarette burning, called smoking machine (SM-MC-01). After the exposure period, urine and blood samples were collected for the functional analyses, and the kidneys were dissected and submitted to histological procedures for morphoquantitative analyses. RESULTSAfter exposure of animals of the Smoking Group, the following were observed: lower weight gain; lower water and feed intake; decreased renal weight, diameter, and volume; reduction in cortical thickness and glomerular volume density; decrease in glomerular and capsular diameter; increase in mesangial density; decreased urine volume; increased levels of glucose, serum creatinine and microalbuminuria; decreased urinary creatinine levels and creatinine clearance rate. CONCLUSIONPassive smoking negatively influences renal morphology and glomerular filtration rate, with effects similar to those described in the literature regarding active smoking.
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Conflict of interest: none.
AUTHORS´ CONTRIBUTION
Carlos Alberto de Moraes: contributed to the conception, planning, laboratory analysis and data interpretation, writing, review and approval of the final version of the article. Mercia Breda-Stella: contributed to laboratory analysis and data interpretation, review and approval of the final version of the article. Cesar Alexandre Fabrega Carvalho: contributed to laboratory analysis and data interpretation, review and approval of the final version of the article.
ISSN:1679-4508
2317-6385
2317-6385
DOI:10.31744/einstein_journal/2021AO6000