Functional diversity of RNAi-associated sRNAs in fungi

Yeast and filamentous fungi have been essential model systems for unveiling the secrets of RNA interference (RNAi). Research on these organisms has contributed to identifying general mechanisms and conserved eukaryotic RNAi machinery that can be found from fungi to mammals. The development of deep s...

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Bibliographic Details
Published inInternational Journal of Molecular Sciences Vol. 14; no. 8; pp. 15348 - 15360
Main Authors Nicolás, Francisco E, Ruiz-Vázquez, Rosa M
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 24.07.2013
Molecular Diversity Preservation International (MDPI)
Subjects
Animals
Caenorhabditis elegans - genetics
esRNA
ex-siRNA
fungi
Gene Expression Regulation, Fungal
masiRNAs
milRNA
Neurospora crassa - genetics
qiRNA
Review
RNA Interference
RNA Replicase - genetics
RNA, Small Interfering - genetics
siRNA
sRNA
Yeasts - genetics
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Summary:Yeast and filamentous fungi have been essential model systems for unveiling the secrets of RNA interference (RNAi). Research on these organisms has contributed to identifying general mechanisms and conserved eukaryotic RNAi machinery that can be found from fungi to mammals. The development of deep sequencing technologies has brought on the last wave of studies on RNAi in fungi, which has been focused on the identification of new types of functional small RNAs (sRNAs). These studies have discovered an unexpected diversity of sRNA, biogenesis pathways and new functions that are the focus of this review.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms140815348