Genetic variations rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population

• Published in: International journal of molecular sciences Vol. 15; no. 11; pp. 19330 - 19341
• Main Authors: Zhang, Yu, Sun, Yan, Chen, Tao, Hu, Hailong, Xie, Wanqin, Qiao, Zhihui, Ding, Na, Xie, Linguo, Li, Sheng, Wang, Wenlong, Xing, Chen, Wang, Yihan, Qie, Yunkai, Wu, Changli
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.10.2014; MDPI
• Subjects: Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group - genetics; Bladder cancer; Case-Control Studies; China; Female; Gene Frequency; Genetic Association Studies; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; genetic variations; genome-wide association studies; Genotype; Genotype & phenotype; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Odds Ratio; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; Risk Factors; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; China
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms151119330

Genome-wide association studies (GWAS) have identified a number of genetic variants associated with risk of bladder cancer in populations of European descent. Here, we assessed association of two of these variants, rs11892031 (2q37.1 region) and rs401681 (5p15.33 region) in a Chinese case-control study, which included 367 bladder cancer cases and 420 controls. We found that the AC genotype of rs11892031 was associated with remarkably decreased risk of bladder cancer (adjusted odds ratio (OR), 0.27; 95% confidence interval (CI), 0.09-0.81; p=0.019), compared with the AA genotype of rs11892031; and that CT/CC genotypes of rs401681 were associated with significantly increased risk of bladder cancer (adjusted OR, 1.79; 95% CI, 1.10-2.91; p=0.02), compared with the TT genotype of rs401681. We further conducted stratification analysis to examine the correlation between single nucleotide polymorphism (SNP) rs11892031/rs401681 and tumor grade/stage. Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p>0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population. The present study suggests that the SNPs rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population. Future analyses will be conducted with more participants recruited in a case-control study.