Impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer

• Published in: Molecular medicine reports Vol. 12; no. 1; pp. 995 - 1001
• Main Authors: XU, KE, LIU, BIN, LIU, YONGYU
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.07.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Aged; Aged, 80 and over; Antigens, CD - genetics; Antigens, CD - metabolism; Antineoplastic Agents - pharmacology; Biotechnology; Brachyury; Cadherins - genetics; Cadherins - metabolism; Cancer therapies; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Cell cycle; Cell Line, Tumor; Cell Survival - drug effects; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; E-cadherin; epithelial-mesenchymal transition; Epithelial-Mesenchymal Transition - genetics; Female; Fetal Proteins - antagonists & inhibitors; Fetal Proteins - genetics; Fetal Proteins - metabolism; Gene Expression Regulation, Neoplastic; Genetic aspects; Growth factors; Humans; Hypotheses; Lung cancer; Lung cancer, Non-small cell; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lymph nodes; Lymphatic Metastasis; Lymphatic system; Male; Medical research; Mesenchyme; Metastases; Metastasis; Middle Aged; N-Cadherin; Neoplasm Staging; non-small cell lung cancer; Non-small cell lung carcinoma; Physiological aspects; Prognosis; Radiation therapy; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Rodents; Signal Transduction; Stem cells; Studies; Survival Analysis; T-Box Domain Proteins - antagonists & inhibitors; T-Box Domain Proteins - genetics; T-Box Domain Proteins - metabolism; Tumorigenesis; Tumors; China; United States > US
• ISSN: 1791-2997; 1791-3004
• DOI: 10.3892/mmr.2015.3348

The objective of the current study was to investigate the impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer (NSCLC). In 115 archived NSCLC tissue samples, the expression of Brachyury was observed to be significantly higher than that in adjacent normal lung tissues. In addition, the current study demonstrated that the expression of Brachyury is closely associated with TNM staging, lymph node metastasis and the prognosis of NSCLC, although not with patient age, gender or tumor differentiation. Brachyury expression is also accompanied by the downregulation of E-cadherin and the upregulation of N-cadherin. Brachyury may promote lung cancer through induction of epithelial-mesenchymal transition, which leads to metastasis and consequent poor prognosis in patients with lung cancer. Furthermore, the present study observed that interfering with Brachyury increases the sensitivity of cells to chemotherapeutic treatment with cisplatin. These results, in combination with those of additional studies, suggest that Brachyury may be used as a novel target for the prevention and treatment of lung cancer.