Sex-dependent associations between MAP3K1 gene polymorphisms and soy products with the gastric cancer risk in Korea: a case-control study

• Published in: BMC gastroenterology Vol. 22; no. 1; p. 513
• Main Authors: Kwak, Jung Hyun, Eun, Chang Soo, Han, Dong Soo, Kim, Yong Sung, Song, Kyu Sang, Choi, Bo Youl, Kim, Hyun Ja
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.12.2022; BioMed Central; BMC
• Subjects: Alcohol; Alleles; Cancer; Case-Control Studies; Cold; Cytokines; Data collection; Demographic aspects; Education; Estrogens; Family medical history; Female; Gastric cancer; Gastroenterology; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Health aspects; Homozygotes; Humans; Infections; Kinases; Male; MAP Kinase Kinase Kinase 1 - genetics; MAP3K1; Odds Ratio; Oncology, Experimental; Phytoestrogens; Polymorphism; Polymorphism, Single Nucleotide; Quality control; Questionnaires; Regression analysis; Risk Factors; Sex; Sex factors in disease; Single Nucleotide; Soy products; Soybean products; Soybeans; Stomach cancer; Stomach Neoplasms; Stomach Neoplasms - genetics; South Korea; United States > US; MAP3K1; Diet; Soy products; Case-control studies; Stomach Neoplasms; Single Nucleotide; Polymorphism
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-022-02569-3

The hormone-dependent effect of MAP3K1 gene polymorphisms may explain sex-specific differences in gastric cancer (GC) risk. Phytoestrogens have been shown to interact with this genetic factor. Here, we investigated the association between MAP3K1 gene polymorphisms and GC risk by sex and whether these associations differ depending on soy products intake. Participants aged 20-79 years were recruited from two hospitals between December 2002 and September 2006. In all, 440 cases and 485 controls were recruited, among, 246 pairs of cases and controls, matched by sex, age (± 5 years), study admission period (± 1 years), and hospital, were included for the analysis. In dominant model, men with the A allele of rs252902 showed significantly increased GC risk (odd ratio; OR=2.19, 95% confidence interval; CI=1.31-3.64) compared to GG homozygotes. When stratified by intake of soy products, men with the A allele of rs252902 and low intake of soy products showed significantly higher GC risk (OR=3.29, 95% CI=1.55-6.78) than that in GG homozygotes. Men with the risk allele of MAP3K1 had a significantly increased GC risk compared to GG homozygotes; this trend was more pronounced in those with low intake of soy products.