Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 106; no. 5; pp. 685 - 695
• Main Authors: Oliveira, Lucinei Roberto, DDS, PhD, Ribeiro-Silva, Alfredo, MD, PhD, Costa, João Paulo Oliveira, DDS, Simões, Aguinaldo Luiz, MD, PhD, Matteo, Miguel Angel Sala Di, PhD, Zucoloto, Sergio, MD, PhD
• Format: Journal Article
• Language: English
• Published: St. Louis, MO Mosby, Inc 01.11.2008; Elsevier
• Subjects: Age Factors; Aged; Aged, 80 and over; Alphapapillomavirus - genetics; Analysis of Variance; Biological and medical sciences; Carcinoma, Squamous Cell - mortality; Dentistry; DNA, Neoplasm - analysis; DNA, Viral - analysis; Female; Humans; Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Mouth Neoplasms - mortality; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Otorhinolaryngology. Stomatology; Prognosis; Proportional Hazards Models; Risk Factors; Surgery; Trans-Activators - analysis; Transcription Factors; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Proteins - analysis; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Human; Prognosis; Stomatology; Oral cavity disease; Malignant tumor; Oral squamous cell carcinoma; Survival; Cancer
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/j.tripleo.2008.07.002

Objectives The aims of this report were to describe the 5-year overall survival (OS) in a group of oral squamous cell carcinoma (OSCC) patients and to investigate the effects of age, gender, anatomic localization, tumor evolution time, smoking and alcohol intake, nodal status, tumoral recurrences, histologic classification, p53 and p63 immunoexpression, human papillomavirus DNA presence, and treatment on the prognostic outcome. Study design Survival curves were generated using Kaplan-Meier method, and univariate and multivariate analyses were made using the log rank test and Cox regression, respectively. Results The 5-year OS was 28.6%, and the univariate analysis showed significant results for p53 and p63 immunoexpression, age, and anatomic localization. The Cox regression demonstrated poor OS for tumors with p53 immunoexpression and for patients aged over 60 years. There were also significant differences in survival depending on the anatomic localizations. Conclusion These results highlight the influence of p53 immunoexpression, age, and anatomic localization in OSCC evolution.