Haplotype inference by maximum parsimony

• Published in: Bioinformatics Vol. 19; no. 14; pp. 1773 - 1780
• Main Authors: Wang, Lusheng, Xu, Ying
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.09.2003; Oxford Publishing Limited (England)
• Subjects: Algorithms; Gene Expression Profiling - methods; Gene Frequency - genetics; Haplotypes - genetics; Humans; Linkage Disequilibrium - genetics; Models, Genetic; Polymorphism, Single Nucleotide - genetics; Receptors, Adrenergic, beta-2 - genetics; Recombination, Genetic - genetics; Reproducibility of Results; Sensitivity and Specificity; Sequence Analysis, DNA - methods
• ISSN: 1367-4803; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/btg239

Motivation: Haplotypes have been attracting increasing attention because of their importance in analysis of many fine-scale molecular-genetics data. Since direct sequencing of haplotype via experimental methods is both time-consuming and expensive, haplotype inference methods that infer haplotypes based on genotype samples become attractive alternatives. Results: (1) We design and implement an algorithm for an important computational model of haplotype inference that has been suggested before in several places. The model finds a set of minimum number of haplotypes that explains the genotype samples. (2) Strong supports of this computational model are given based on the computational results on both real data and simulation data. (3) We also did some comparative study to show the strength and weakness of this computational model using our program. Availability: The software HAPAR is free for non-commercial uses. Available upon request (lwang@cs.cityu.edu.hk).