Macrophage subsets in the adipose tissue could be modified by sex and the reproductive age of women

Abstract The presence of proinflammatory monocytes/macrophages (CD14+CD16+) has been documented in conditions of inflammation, such as atherosclerosis. We analysed the proportion of proinflammatory monocytes/macrophages in perirenal and perivascular fat in healthy living kidney donors with regard to...

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Published inAtherosclerosis Vol. 241; no. 1; pp. 255 - 258
Main Authors Králová Lesná, Ivana, Poledne, Rudolf, Fronek, Jiri, Králová, Anna, Sekerková, Alena, Thieme, Filip, Pitha, Jan
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.07.2015
Subjects
Adipose tissue
Adipose Tissue - immunology
Adult
Age Factors
Aged
Aging - immunology
Biomarkers - analysis
Cardiovascular
Female
GPI-Linked Proteins - analysis
Health Status Disparities
Humans
Inflammation - immunology
Lipopolysaccharide Receptors - analysis
Macrophages - immunology
Male
Middle Aged
Monocytes/macrophages
Postmenopause
Premenopause
Receptors, IgG - analysis
Reproduction
Reproductive status
Risk Factors
Sex
Sex Factors
Monocytes/macrophages
Adipose tissue
Sex
Reproductive status
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Summary:Abstract The presence of proinflammatory monocytes/macrophages (CD14+CD16+) has been documented in conditions of inflammation, such as atherosclerosis. We analysed the proportion of proinflammatory monocytes/macrophages in perirenal and perivascular fat in healthy living kidney donors with regard to sex and age reflecting reproductive status in women; therefore, women were further divided to younger and older group (younger and older than 51 years) reflecting potential age of menopause. Monocyte/macrophages were identified as CD14+ mononuclear cells and divided into subpopulations based on the co-expression of CD16. We found no differences in the monocyte/macrophage content between men (n = 15) and women (n = 28). Conversely, we observed a higher proportion of double positive CD14+CD16+ monocytes/macrophages in older women (n = 14) compared to younger women (n = 14). In addition, a strong correlation was found between the monocyte/macrophage content in fat and age only in older women. Therefore, proinflammatory monocytes/macrophages (CD14+CD16+) should be evaluated according to the sex and age.
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ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.03.018