Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico

• Published in: International journal of molecular sciences Vol. 16; no. 9; pp. 21539 - 21554
• Main Authors: Cahua-Pablo, José Ángel, Cruz, Miguel, Méndez-Palacios, Abigail, Antúnez-Ortiz, Diana Lizzete, Vences-Velázquez, Amalia, del Carmen Alarcón-Romero, Luz, Parra, Esteban Juan, Tello-Flores, Vianet Argelia, Leyva-Vázquez, Marco Antonio, Valladares-Salgado, Adán, Pérez-Macedonio, Claudia Paola, Flores-Alfaro, Eugenia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.09.2015; MDPI
• Subjects: Adult; Alleles; Case-Control Studies; Cholesterol Ester Transfer Proteins - genetics; Cross-Sectional Studies; ESR1 haplotype; Estrogen Receptor alpha - genetics; Female; Gene Frequency; Genes; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Lipoprotein Lipase - genetics; LPL and CETP polymorphisms; Metabolic disorders; metabolic syndrome; Metabolic Syndrome - epidemiology; Metabolic Syndrome - genetics; Mexico - epidemiology; Middle Aged; Polymorphism; Polymorphism, Single Nucleotide; Women; Mexico; metabolic syndrome; LPL and CETP polymorphisms; ESR1 haplotype
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms160921539

Metabolic syndrome (MetS) is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD). Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR) = 2.9; p = 0.013) in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04). Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006). In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001). In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.