Association of lipoprotein lipase (LPL) gene variants with hyperlipidemic acute pancreatitis in southeastern Chinese population

• Published in: Archives of Endocrinology and Metabolism Vol. 68; p. e230195
• Main Authors: Li, Yingyi, Cai, Hehui, Lin, Yancheng, Huang, Zhipeng, Zhou, Apei, Huang, Tianhao, Zeng, Yue-e, Ye, Meizhen, Guo, Guiyuan, Huang, Zicheng
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Endocrinologia e Metabologia 01.01.2024; Brazilian Society of Endocrinology and Metabolism
• Subjects: Acute Disease; Brief Report; China - epidemiology; Genotype; Humans; hyperlipidemic acute pancreatitis; L279V; Lipoprotein Lipase - genetics; LPL; Pancreatitis - diagnosis; Pancreatitis - genetics; rs371282890; Triglycerides; China; L279V; LPL; hyperlipidemic acute pancreatitis; rs371282890
• ISSN: 2359-3997; 2359-4292
• DOI: 10.20945/2359-4292-2023-0195

The study aims to explore the relationship between lipoprotein lipase variants and hyperlipidemic acute pancreatitis (HLAP) in the southeastern Chinese population. In total, 80 participants were involved in this study (54 patients with HLAP and 26 controls). All coding regions and intron-exon boundaries of the gene were sequenced. The correlations between variants and phenotypes were also analysed. The rate of rare variants in the HLAP group is 14.81% (8 of 54), higher than in controls. Among the detected four variants (rs3735959, rs371282890, rs761886494 and rs761265900), the most common variant was rs371282890. Further analysis demonstrated that subjects with rs371282890 "GC" genotype had a 2.843-fold higher risk for HLAP (odds ratio [OR]: 2.843, 95% confidence interval [CI]: 1.119-7.225, = 0.028) than subjects with the "CC" genotype. After adjusting for sex, the association remained significant (adjusted OR: 3.083, 95% CI: 1.208-7.869, p = 0.018). Subjects with rs371282890 "GC" genotype also exhibited significantly elevated total cholesterol, triglyceride and non-high-density lipoprotein cholesterol levels in all the participants and the HLAP group ( < 0.05). Detecting rare variants in might be valuable for identifying higher-risk patients with HLAP and guiding future individualised therapeutic strategies.