Genetic and Neuroendocrine Regulation of the Postpartum Brain

Highlights • Top 700 maternal genes include multiple reward and addiction-related genes. • Top maternal genes provide new candidates for postpartum depression. • Top maternal genes show strong connection to disorders with social deficits. • Top maternal genes provide new insights into prolactin, oxy...

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Bibliographic Details
Published inFrontiers in neuroendocrinology Vol. 42; pp. 1 - 17
Main Authors Gammie, Stephen C, Driessen, Terri M, Zhao, Changjiu, Saul, Michael C, Eisinger, Brian E
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2016
Subjects
Addiction
Animals
Depression
Depression, Postpartum - genetics
Depression, Postpartum - metabolism
Endocrinology & Metabolism
Female
Humans
Maternal
Mental health
MicroRNA
Oxytocin
Postpartum
Postpartum Period - genetics
Postpartum Period - metabolism
Prolactin
Reward
Social behavior
Maternal
Social behavior
Addiction
Oxytocin
Prolactin
Mental health
Depression
microRNA
Reward
Postpartum
MicroRNA
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Summary:Highlights • Top 700 maternal genes include multiple reward and addiction-related genes. • Top maternal genes provide new candidates for postpartum depression. • Top maternal genes show strong connection to disorders with social deficits. • Top maternal genes provide new insights into prolactin, oxytocin, and steroid signaling. • miRNAs are part of a complex transcriptional regulation of the maternal brain.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0091-3022
1095-6808
DOI:10.1016/j.yfrne.2016.05.002