miR-132 enhances HIV-1 replication

Abstract MicroRNAs upregulated during CD4+ T cell activation may contribute to the increased efficiency of HIV-1 replication seen following perturbation of the resting state. We have found miR-132 to be highly upregulated following CD4+ T cell activation, and show that miR-132 potentiates viral repl...

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Published inVirology (New York, N.Y.) Vol. 438; no. 1; pp. 1 - 4
Main Authors Chiang, Karen, Liu, Hongbing, Rice, Andrew P
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 30.03.2013
Subjects
Adult
Aged
Aged, 80 and over
CD4-Positive T-Lymphocytes - virology
Cells, Cultured
Gene Expression Profiling
HIV
HIV-1 - genetics
HIV-1 - pathogenicity
HIV-1 - physiology
Host-Pathogen Interactions
Humans
Infectious Disease
Lymphocyte Activation
MeCP2
microRNA
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
miR-132
Virus Replication
MeCP2
microRNA
HIV
miR-132
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Summary:Abstract MicroRNAs upregulated during CD4+ T cell activation may contribute to the increased efficiency of HIV-1 replication seen following perturbation of the resting state. We have found miR-132 to be highly upregulated following CD4+ T cell activation, and show that miR-132 potentiates viral replication in the Jurkat CD4+ T cell line. Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Present address: Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2012.12.016