Chromatin assembly: Journey to the CENter of the chromosome

All eukaryotic genomes are packaged into basic units of DNA wrapped around histone proteins called nucleosomes. The ability of histones to specify a variety of epigenetic states at defined chromatin domains is essential for cell survival. The most distinctive type of chromatin is found at centromere...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 214; no. 1; pp. 13 - 24
Main Authors Chen, Chin-Chi, Mellone, Barbara G
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 04.07.2016
The Rockefeller University Press
Subjects
Animals
Autoantigens
Cellular biology
Centromere - metabolism
Centromere Protein A
Chromatin
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone
Chromosomes - metabolism
Deoxyribonucleic acid
DNA
DNA Replication
Eukaryotes
Genomes
Humans
Proteins
Reviews
Transcription, Genetic
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Summary:All eukaryotic genomes are packaged into basic units of DNA wrapped around histone proteins called nucleosomes. The ability of histones to specify a variety of epigenetic states at defined chromatin domains is essential for cell survival. The most distinctive type of chromatin is found at centromeres, which are marked by the centromere-specific histone H3 variant CENP-A. Many of the factors that regulate CENP-A chromatin have been identified; however, our understanding of the mechanisms of centromeric nucleosome assembly, maintenance, and reorganization remains limited. This review discusses recent insights into these processes and draws parallels between centromeric and noncentromeric chromatin assembly mechanisms.
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ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201605005