Functional imaging of implicit marijuana associations during performance on an Implicit Association Test (IAT)

• Published in: Behavioural brain research Vol. 256; pp. 494 - 502
• Main Authors: L. Ames, Susan, Grenard, Jerry L., W. Stacy, Alan, Xiao, Lin, He, Qinghua, Wong, Savio W., Xue, Gui, W. Wiers, Reinout, Bechara, Antoine
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.11.2013; Elsevier
• Subjects: Adolescent; Adult; Association; Associative processes; Behavioral psychophysiology; Biological and medical sciences; Brain Mapping; Cannabis; Female; fMRI; Fundamental and applied biological sciences. Psychology; Habit; Humans; Implicit cognition; Magnetic Resonance Imaging; Male; Marijuana Abuse - physiopathology; Marijuana IAT; Marijuana Smoking - physiopathology; Memory associations; Prefrontal Cortex - physiopathology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Vertebrates: nervous system and sense organs; Habit; fMRI; Implicit cognition; Memory associations; Marijuana IAT; Associative processes; Memory; Implicit Association Test Greenwald et al; Associative relation; Psychometrics; Cognition; Nuclear magnetic resonance imaging; Marijuana; Performance; Functional imaging
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2013.09.013

•Marijuana users showed activity in the caudate/putamen on compatible IAT trials.•Non-users showed activity in the inferior frontal gyrus on incompatible IAT trials.•Findings are consistent with a dual process framework of appetitive behaviors.•Implicit associations underlying habit are mediated through the striatum.•Reflective/controlled behaviors are mediated through the prefrontal cortex. This research evaluated the neural correlates of implicit associative memory processes (habit-based processes) through the imaging (fMRI) of a marijuana Implicit Association Test. Drug-related associative memory effects have been shown to consistently predict level of drug use. To observe differences in neural activity of associative memory effects, this study compared 13 heavy marijuana users and 15 non-using controls, ranging in age from 18 to 25, during performance of a marijuana Implicit Association Test (IAT). Group by condition interactions in the putamen, caudate, and right inferior frontal gyrus were observed. Relative to non-users, marijuana users showed greater bilateral activity in the dorsal striatum (caudate and putamen) during compatible trials focused on perceived positive outcomes of use. Alternatively, relative to the marijuana-using group, the non-users showed greater activity in the right inferior frontal gyrus during incompatible trials, which require more effortful processing of information. Further, relative to fixation, heavy users showed bilateral activity in the caudate and putamen, hippocampus and some frontal regions during compatible trials and no significant activity during incompatible trials. The non-using group showed greater activity in frontal regions during incompatible trials relative to fixation and no significant activity during compatible trials. These findings are consistent with a dual process framework of appetitive behaviors proposing that (1) implicit associations underlying habit are mediated through neural circuitry dependent on the striatum, and (2) deliberative/controlled behaviors are mediated through circuitry more dependent on the prefrontal cortex.