Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent

• Published in: Experimental and therapeutic medicine Vol. 9; no. 2; pp. 341 - 344
• Main Authors: ZHONG, SHAO-MIN, SUN, NAN, LIU, HUI-XIAN, NIU, YUE-QING, WU, YAN
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.02.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Dermatologic agents; Dermatology; Drug therapy; emulsions; Enzymes; Formulae, receipts, prescriptions; Fungi; Genetic aspects; Health aspects; Hormone replacement therapy; Lignin; lignin peroxidase; melanin; Melanosis; melasma; Patients; Peroxidase; Physiological aspects; Risk factors; skin lightening; Statistical analysis; statistics; Sunscreen; Variance analysis; China; Beijing China; United States > US; melasma; lignin peroxidase; emulsions; melanin; skin lightening; statistics
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2014.2118

The aim of the present study was to evaluate the efficacy and safety of lignin peroxidase (LIP) as a skin-lightening agent in patients with melasma. A self-controlled clinical study was performed in 31 women who had melasma on both sides of the face. This study involved 8 weeks of a full-face product treatment. The skin color was measured at days 0, 7, 28 and 56 using a chromameter on the forehead and cheeks. Standardized digital photographic images of each side of the face of all subjects were captured by a complexion analysis system. Clinical scores of the pigmentation were determined by two dermatologists. After using the LIP whitening lotion for 7 days, the luminance (L*) values of the melasma and the normal skin were significantly increased from baseline. The L* values continued to increase at days 28 and 56. The melasma area severity index (MASI) score was statistically decreased after 28 days of treatment. No treatment-related adverse events were observed. LIP whitening lotion was able to eliminate the skin pigmentation after 7 days of treatment, and provides a completely innovative approach to rapid skin lightening. The LIP whitening lotion exhibited good compatibility and was well tolerated.