ST2 and Prognosis in Acutely Decompensated Heart Failure: The International ST2 Consensus Panel

ST2 is a member of the interleukin (IL) 1 receptor family that exists in 2 forms, a transmembrane receptor (ST2L) and a soluble receptor (sST2). The ligand of ST2 is IL-33, known to be involved in reducing tissue fibrosis and myocyte hypertrophy in mechanically strained hearts. Through its ability t...

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Published inThe American journal of cardiology Vol. 115; no. 7; pp. 26B - 31B
Main Authors Januzzi, James L., MD, Mebazaa, Alexandre, MD, PhD, Di Somma, Salvatore, MD, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 02.04.2015
Elsevier Limited
Subjects
Acute Disease
Biomarkers
Biomarkers - blood
Cardiomyocytes
Cardiovascular
Consensus
Expected values
Heart attacks
Heart failure
Heart Failure - blood
Humans
Interleukin-1 Receptor-Like 1 Protein
Ligands
Medical prognosis
Mortality
Patients
Prognosis
Receptors, Cell Surface - blood
Studies
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Summary:ST2 is a member of the interleukin (IL) 1 receptor family that exists in 2 forms, a transmembrane receptor (ST2L) and a soluble receptor (sST2). The ligand of ST2 is IL-33, known to be involved in reducing tissue fibrosis and myocyte hypertrophy in mechanically strained hearts. Through its ability to act as a decoy receptor, sST2 blocks the beneficial effects that occur when IL-33 attempts to bind to ST2L; experimentally, this leads to cardiac hypertrophy, fibrosis, and ventricular dysfunction. In patients with acutely decompensated heart failure, elevated concentrations of sST2 are strongly associated with the presence and severity of the diagnosis and powerfully predict increased risk of heart failure complications including arrhythmia, pump failure, or death, independent of natriuretic peptides and other established or emerging biomarkers. The role of sST2 measurement in acutely decompensated heart failure evaluation and management will be discussed.
Bibliography:ObjectType-Article-2
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ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2015.01.037