Malignant peripheral nerve sheath tumor of the vulva, an unusual differential diagnosis for vulvar mass

• Published in: International journal of surgery case reports Vol. 5; no. 11; pp. 793 - 795
• Main Authors: Özdal, Bülent, Öz, Murat, Korkmaz, Elmas, Ataoğlu, Ömür, Güngör, Tayfun, Meydanli, Mehmet Mutlu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2014; Elsevier
• Subjects: Malignant schwannoma; MPNST; Surgery; Vulvar cancer; Malignant schwannoma; Vulvar cancer; MPNST
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2014.09.006

Abstract INTRODUCTION Malignant peripheral nerve sheath tumors (MPNSTs) are rare, up to one half of the MPNSTs occur in patients with neurofibromatosis type-1 (NF-1), while the rest are sporadic. Here, we present a 52-year-old woman with MPNST of the vulva without NF-1. We will discuss basics of the disease, treatment options and follow-up strategies. PRESENTATION OF CASE 52-year-old female admitted to our hospital with complaint of abnormal uterine bleeding and rapidly growing vulvar mass. Excisional biopsy of the mass showed MPNST of the vulva. Afterwards, the patient underwent radical vulvectomy with inguinofemoral lymph node dissection. Short after the surgery, multiple lung metastasis were shown and responded to chemotherapy, but rapid local recurrence occurred short after the completion of the chemotherapy. DISCUSSION The primary treatment option in MPNSTs is surgical excision with or without adjuvant therapy. There is not enough data about the role of systemic chemotherapy in the management of MPNSTs and it still remains controversial. CONCLUSION In general, radiation therapy has not been demonstrated to improve overall survival. Complete surgical resection of the primary tumor is the mainstay of the treatment.