Protective effects of tanshinone IIA on endothelial progenitor cells injured by tumor necrosis factor-α

Tanshinone IIA (Tan IIA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction and associated inflammatory processes have a critical role in the development of athe...

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Published inMolecular medicine reports Vol. 12; no. 3; pp. 4055 - 4062
Main Authors WANG, XING-XIANG, YANG, JIN-XIU, PAN, YAN-YUN, ZHANG, YE-FEI
Format Journal Article
LanguageEnglish
Published Greece D.A. Spandidos 01.09.2015
Spandidos Publications
Spandidos Publications UK Ltd
Subjects
Animals
Arteriosclerosis
Atherosclerosis
Care and treatment
CD40 antigen
CD40 Ligand - metabolism
Cell Adhesion - drug effects
Cell Movement - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Chemokine CCL2 - metabolism
Chinese medicine
Development and progression
Diterpenes, Abietane - pharmacology
endothelial progenitor cell
Endothelial Progenitor Cells - cytology
Endothelial Progenitor Cells - drug effects
Endothelial Progenitor Cells - metabolism
Epidermal growth factor
Health aspects
Inflammation
Interleukin 6
Interleukin-6 - metabolism
Leukocyte migration
Male
Medicine, Chinese
Medicine, Chinese Traditional
Microscopy, Fluorescence
migration
Monocyte chemoattractant protein
Monocyte chemoattractant protein 1
Necrosis
paracrine
Paracrine signalling
Protective Agents - pharmacology
Rats
Rats, Sprague-Dawley
Rodents
Stem cells
Studies
tanshinone IIA
Traditional Chinese medicine
Tumor necrosis factor
Tumor Necrosis Factor-alpha - toxicity
Tumor necrosis factor-TNF
Tumor necrosis factor-α
vasculogenesis
China
United States > US
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Abstract Tanshinone IIA (Tan IIA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction and associated inflammatory processes have a critical role in the development of atherosclerosis. Endothelial progenitor cells (EPCs) have been demonstrated to be involved in certain aspects of the endothelial repair process. The present study aimed to investigate the putative protective effects of Tan IIA on EPCs injured by tumor necrosis factor-α (TNF-α). The potential effects of Tan IIA on TNF-α-stimulated EPC proliferation, migration, adhesion, in vitro tube formation ability and paracrine activity were investigated in the current study. The results indicated that TNF-α impaired EPC proliferation, migration, adhesion capacity and vasculogenesis ability in vitro as well as promoted EPC secretion of inflammatory cytokines, including monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and soluble CD40 ligand (sCD40L). However, Tan IIA was able to reverse these effects. In conclusion, these findings demonstrated that Tan IIA may have the potential to protect EPCs against damage induced by TNF-α. Therefore, these results may provide evidence for the pharmacological basis of Tan IIA and its potential use in the prevention and treatment of early atherosclerosis associated with EPC and endothelial damage.
AbstractList Tanshinone IIA (Tan IIA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction and associated inflammatory processes have a critical role in the development of atherosclerosis. Endothelial progenitor cells (EPCs) have been demonstrated to be involved in certain aspects of the endothelial repair process. The present study aimed to investigate the putative protective effects of Tan IIA on EPCs injured by tumor necrosis factor-α (TNF-α). The potential effects of Tan IIA on TNF-α-stimulated EPC proliferation, migration, adhesion, in vitro tube formation ability and paracrine activity were investigated in the current study. The results indicated that TNF-α impaired EPC proliferation, migration, adhesion capacity and vasculogenesis ability in vitro as well as promoted EPC secretion of inflammatory cytokines, including monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and soluble CD40 ligand (sCD40L). However, Tan IIA was able to reverse these effects. In conclusion, these findings demonstrated that Tan IIA may have the potential to protect EPCs against damage induced by TNF-α. Therefore, these results may provide evidence for the pharmacological basis of Tan IIA and its potential use in the prevention and treatment of early atherosclerosis associated with EPC and endothelial damage.
Tanshinone IIA (Tan IIA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction and associated inflammatory processes have a critical role in the development of atherosclerosis. Endothelial progenitor cells (EPCs) have been demonstrated to be involved in certain aspects of the endothelial repair process. The present study aimed to investigate the putative protective effects of Tan IIA on EPCs injured by tumor necrosis factor-α (TNF-α). The potential effects of Tan IIA on TNF-α-stimulated EPC proliferation, migration, adhesion, in vitro tube formation ability and paracrine activity were investigated in the current study. The results indicated that TNF-α impaired EPC proliferation, migration, adhesion capacity and vasculogenesis ability in vitro as well as promoted EPC secretion of inflammatory cytokines, including monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and soluble CD40 ligand (sCD40L). However, Tan IIA was able to reverse these effects. In conclusion, these findings demonstrated that Tan IIA may have the potential to protect EPCs against damage induced by TNF-α. Therefore, these results may provide evidence for the pharmacological basis of Tan IIA and its potential use in the prevention and treatment of early atherosclerosis associated with EPC and endothelial damage.
Tanshinone ⅡA (Tan ⅡA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction and associated inflammatory processes have a critical role in the development of atherosclerosis. Endothelial progenitor cells (EPCs) have been demonstrated to be involved in certain aspects of the endothelial repair process. The present study aimed to investigate the putative protective effects of Tan ⅡA on EPCs injured by tumor necrosis factor‑α (TNF‑α). The potential effects of Tan ⅡA on TNF-α-stimulated EPC proliferation, migration, adhesion, in vitro tube formation ability and paracrine activity were investigated in the current study. The results indicated that TNF‑α impaired EPC proliferation, migration, adhesion capacity and vasculogenesis ability in vitro as well as promoted EPC secretion of inflammatory cytokines, including monocyte chemoattractant protein‑1 (MCP‑1), interleukin‑6 (IL‑6) and soluble CD40 ligand (sCD40L). However, Tan ⅡA was able to reverse these effects. In conclusion, these findings demonstrated that Tan ⅡA may have the potential to protect EPCs against damage induced by TNF‑α. Therefore, these results may provide evidence for the pharmacological basis of Tan ⅡA and its potential use in the prevention and treatment of early atherosclerosis associated with EPC and endothelial damage.
Tanshinone HA (Tan HA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction and associated inflammatory processes have a critical role in the development of atherosclerosis. Endothelial progenitor cells (EPCs) have been demonstrated to be involved in certain aspects of the endothelial repair process. The present study aimed to investigate the putative protective effects of Tan HA on EPCs injured by tumor necrosis factor-α (TNF-α). The potential effects of Tan HA on TNF-α-stimulated EPC proliferation, migration, adhesion, in vitro tube formation ability and paracrine activity were investigated in the current study. The results indicated that TNF-α impaired EPC proliferation, migration, adhesion capacity and vasculogenesis ability in vitro as well as promoted EPC secretion of inflammatory cytokines, including monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and soluble CD40 ligand (sCD40L). However, Tan HA was able to reverse these effects. In conclusion, these findings demonstrated that Tan HA may have the potential to protect EPCs against damage induced by TNF-α. Therefore, these results may provide evidence for the pharmacological basis of Tan HA and its potential use in the prevention and treatment of early atherosclerosis associated with EPC and endothelial damage.
Tanshinone HA (Tan HA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction and associated inflammatory processes have a critical role in the development of atherosclerosis. Endothelial progenitor cells (EPCs) have been demonstrated to be involved in certain aspects of the endothelial repair process. The present study aimed to investigate the putative protective effects of Tan HA on EPCs injured by tumor necrosis factor-α (TNF-α). The potential effects of Tan HA on TNF-α-stimulated EPC proliferation, migration, adhesion, in vitro tube formation ability and paracrine activity were investigated in the current study. The results indicated that TNF-α impaired EPC proliferation, migration, adhesion capacity and vasculogenesis ability in vitro as well as promoted EPC secretion of inflammatory cytokines, including monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and soluble CD40 ligand (sCD40L). However, Tan HA was able to reverse these effects. In conclusion, these findings demonstrated that Tan HA may have the potential to protect EPCs against damage induced by TNF-α. Therefore, these results may provide evidence for the pharmacological basis of Tan HA and its potential use in the prevention and treatment of early atherosclerosis associated with EPC and endothelial damage. Key words: endothelial progenitor cell, migration, paracrine, tanshinone HA, tumor necrosis factor-α, vasculogenesis
Audience Academic
Author WANG, XING-XIANG
YANG, JIN-XIU
ZHANG, YE-FEI
PAN, YAN-YUN
AuthorAffiliation 1 Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
2 Department of Cardiology, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China
3 Department of Emergency, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
AuthorAffiliation_xml – name: 1 Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
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  fullname: YANG, JIN-XIU
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  givenname: YAN-YUN
  surname: PAN
  fullname: PAN, YAN-YUN
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  givenname: YE-FEI
  surname: ZHANG
  fullname: ZHANG, YE-FEI
  organization: Department of Emergency, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
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Cites_doi 10.1161/01.RES.0000083812.30141.74
10.1016/j.jep.2007.09.025
10.1371/journal.pone.0046511
10.3727/096368912X659899
10.1126/science.275.5302.964
10.1016/j.jep.2006.05.004
10.1111/j.1742-7843.2008.00342.x
10.1128/AAC.47.6.1836-1841.2003
10.1016/j.cjca.2012.05.014
10.3109/14653240903446910
10.1631/jzus.B1001008
10.2174/0929867053363397
10.1161/01.CIR.0000132468.82942.F5
10.1016/j.intimp.2005.05.005
10.1093/emboj/18.14.3964
10.1177/0091270005282630
10.1371/journal.pone.0100045
10.1161/hc0902.104353
10.1056/NEJM199901143400207
10.1161/01.CIR.0000038140.80105.AD
10.1016/j.yjmcc.2014.02.012
10.1016/j.ejphar.2007.04.031
10.1016/j.phymed.2013.09.012
10.1111/j.1365-2184.2011.00764.x
10.1056/NEJMoa022287
10.1080/10715760000301471
10.1016/j.ijcard.2007.05.111
10.1016/j.jep.2010.07.040
10.1016/j.jsbmb.2009.01.011
10.1161/01.RES.0000146672.10582.17
10.1056/NEJMra040291
10.1056/NEJM199110033251404
10.1161/01.CIR.0000096490.16596.A6
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References Lerman, Edwards, Hallett, Heublein, Sandberg, Burnett (b18-mmr-12-03-4055) 1991; 325
Jiang, Ruan, Gu, Zhou, Guo (b26-mmr-12-03-4055) 1998; 19
Fu, Huang, Liu, Pi, Chen, Liu (b5-mmr-12-03-4055) 2007; 568
Epstein, Stabile, Kinnaird, Lee, Clavijo, Burnett (b32-mmr-12-03-4055) 2004; 109
Humbert, Sitbon, Simonneau (b8-mmr-12-03-4055) 2004; 351
Fang, Lin, Yuan, Yang, Liu, Zhang (b35-mmr-12-03-4055) 2008; 115
Lin, Wang, Liu, Yang, Han (b34-mmr-12-03-4055) 2006; 108
Ji, Chai, Xing, Nan, Yang, Tang (b23-mmr-12-03-4055) 2010; 11
Yang, Pan, Zhao, Wang (b9-mmr-12-03-4055) 2013; 22
Jiang, Lau, Hon, Mak, Woo, Fung (b1-mmr-12-03-4055) 2005; 12
Yang, Chen, Pan, Han, Chen, Hu (b14-mmr-12-03-4055) 2012; 7
Zhang, Yang, Bian (b11-mmr-12-03-4055) 2014; 72
Chen, Zhong, Sun, Zhou, Zhao (b12-mmr-12-03-4055) 2011; 44
Ross (b16-mmr-12-03-4055) 1999; 340
Yang, Zhang, Lin, Wang, Shi, Liu, Ji (b17-mmr-12-03-4055) 2009; 104
Hill, Zalos, Halcox, Schenke, Waclawiw, Quyyumi, Finkel (b19-mmr-12-03-4055) 2003; 348
Inoue, Egashira, Ni (b30-mmr-12-03-4055) 2002; 106
Griese, Ehsan, Melo (b21-mmr-12-03-4055) 2003; 108
Li, Duan, Liu, Xu (b10-mmr-12-03-4055) 2010; 131
Yang, Tang, Wang (b13-mmr-12-03-4055) 2010; 12
Libby, Ridker, Maseri (b28-mmr-12-03-4055) 2002; 105
Ling, Nheu, Dai, Guo, Komesaroff (b6-mmr-12-03-4055) 2008; 128
McPherson, Davies (b33-mmr-12-03-4055) 2012; 28
Fan, Gao, Wang (b24-mmr-12-03-4055) 2009; 113
Niu, Ichimori, Yang, Hirota, Hoshiai, Li, Nakazawa (b27-mmr-12-03-4055) 2000; 33
Charo, Taubman (b31-mmr-12-03-4055) 2004; 95
Asahara, Takahashi, Masuda (b20-mmr-12-03-4055) 1999; 18
Zhou, Zuo, Chow (b2-mmr-12-03-4055) 2005; 45
Ding, Ye, Zhao, Yuan, Guo (b15-mmr-12-03-4055) 2005; 5
Wang, Sha, Lesniak, Schacht (b4-mmr-12-03-4055) 2003; 47
Zhang, Yu, Jia, Leung, Siow, Man, Zhu (b3-mmr-12-03-4055) 2002; 23
Shindo, Tanemura, Yata, Hamada, Shibata, Umeda, Asakura, Toma, Sakaida, Fujisawa (b29-mmr-12-03-4055) 2014; 9
Asahara, Murohara, Sullivan (b7-mmr-12-03-4055) 1997; 275
Werner, Junk, Laufs, Link, Walenta, Bohm, Nickenig (b22-mmr-12-03-4055) 2003; 93
Chang, Chu, Wang, Wu, Bi, Pang, Huang (b25-mmr-12-03-4055) 2014; 21
17692965 - Int J Cardiol. 2008 Aug 29;128(3):350-8
23295102 - Cell Transplant. 2013;22(8):1325-36
24936646 - PLoS One. 2014;9(6):e100045
12584367 - N Engl J Med. 2003 Feb 13;348(7):593-600
19429433 - J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):275-80
10406801 - EMBO J. 1999 Jul 15;18(14):3964-72
24594319 - J Mol Cell Cardiol. 2014 Jul;72:85-94
20669352 - J Zhejiang Univ Sci B. 2010 Aug;11(8):618-26
20659541 - J Ethnopharmacol. 2010 Oct 5;131(3):562-6
16797899 - J Ethnopharmacol. 2006 Nov 24;108(2):217-22
15638738 - Curr Med Chem. 2005;12(2):237-46
16291709 - J Clin Pharmacol. 2005 Dec;45(12):1345-59
22902153 - Can J Cardiol. 2012 Nov-Dec;28(6):662-6
24157079 - Phytomedicine. 2014 Feb 15;21(3):207-16
12760856 - Antimicrob Agents Chemother. 2003 Jun;47(6):1836-41
12829619 - Circ Res. 2003 Jul 25;93(2):e17-24
16039554 - Int Immunopharmacol. 2005 Oct;5(11):1641-51
23071580 - PLoS One. 2012;7(10):e46511
10375758 - Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):47-50
10993484 - Free Radic Res. 2000 Sep;33(3):305-12
21702858 - Cell Prolif. 2011 Aug;44(4):352-9
11877368 - Circulation. 2002 Mar 5;105(9):1135-43
12466055 - Acta Pharmacol Sin. 2002 Dec;23(12):1163-8
15514167 - Circ Res. 2004 Oct 29;95(9):858-66
9887164 - N Engl J Med. 1999 Jan 14;340(2):115-26
1886637 - N Engl J Med. 1991 Oct 3;325(14):997-1001
12438296 - Circulation. 2002 Nov 19;106(21):2700-6
14597586 - Circulation. 2003 Nov 25;108(21):2710-5
19067674 - Basic Clin Pharmacol Toxicol. 2009 Feb;104(2):87-92
20196696 - Cytotherapy. 2010 Apr;12(2):251-9
9020076 - Science. 1997 Feb 14;275(5302):964-7
15197154 - Circulation. 2004 Jun 15;109(23):2826-31
17537428 - Eur J Pharmacol. 2007 Jul 30;568(1-3):213-21
15459304 - N Engl J Med. 2004 Sep 30;351(14):1425-36
17997063 - J Ethnopharmacol. 2008 Jan 17;115(2):217-22
Shindo (key20180108020330_b29-mmr-12-03-4055) 2014; 9
Zhang (key20180108020330_b11-mmr-12-03-4055) 2014; 72
Ross (key20180108020330_b16-mmr-12-03-4055) 1999; 340
Chen (key20180108020330_b12-mmr-12-03-4055) 2011; 44
Yang (key20180108020330_b13-mmr-12-03-4055) 2010; 12
Jiang (key20180108020330_b26-mmr-12-03-4055) 1998; 19
Epstein (key20180108020330_b32-mmr-12-03-4055) 2004; 109
Yang (key20180108020330_b17-mmr-12-03-4055) 2009; 104
Yang (key20180108020330_b14-mmr-12-03-4055) 2012; 7
Yang (key20180108020330_b9-mmr-12-03-4055) 2013; 22
Wang (key20180108020330_b4-mmr-12-03-4055) 2003; 47
Inoue (key20180108020330_b30-mmr-12-03-4055) 2002; 106
Li (key20180108020330_b10-mmr-12-03-4055) 2010; 131
Ding (key20180108020330_b15-mmr-12-03-4055) 2005; 5
Ling (key20180108020330_b6-mmr-12-03-4055) 2008; 128
Charo (key20180108020330_b31-mmr-12-03-4055) 2004; 95
McPherson (key20180108020330_b33-mmr-12-03-4055) 2012; 28
Griese (key20180108020330_b21-mmr-12-03-4055) 2003; 108
Jiang (key20180108020330_b1-mmr-12-03-4055) 2005; 12
Lerman (key20180108020330_b18-mmr-12-03-4055) 1991; 325
Zhang (key20180108020330_b3-mmr-12-03-4055) 2002; 23
Asahara (key20180108020330_b20-mmr-12-03-4055) 1999; 18
Libby (key20180108020330_b28-mmr-12-03-4055) 2002; 105
Fu (key20180108020330_b5-mmr-12-03-4055) 2007; 568
Lin (key20180108020330_b34-mmr-12-03-4055) 2006; 108
Ji (key20180108020330_b23-mmr-12-03-4055) 2010; 11
Hill (key20180108020330_b19-mmr-12-03-4055) 2003; 348
Chang (key20180108020330_b25-mmr-12-03-4055) 2014; 21
Humbert (key20180108020330_b8-mmr-12-03-4055) 2004; 351
Fang (key20180108020330_b35-mmr-12-03-4055) 2008; 115
Werner (key20180108020330_b22-mmr-12-03-4055) 2003; 93
Niu (key20180108020330_b27-mmr-12-03-4055) 2000; 33
Asahara (key20180108020330_b7-mmr-12-03-4055) 1997; 275
Zhou (key20180108020330_b2-mmr-12-03-4055) 2005; 45
Fan (key20180108020330_b24-mmr-12-03-4055) 2009; 113
References_xml – volume: 19
  start-page: 47
  year: 1998
  end-page: 50
  ident: b26-mmr-12-03-4055
  article-title: Effects of tanshinone II-A sulfonate on adhesion molecule expression of endothelial cells and platelets in vitro
  publication-title: Acta Pharmacol Sin
  contributor:
    fullname: Guo
– volume: 275
  start-page: 964
  year: 1997
  end-page: 967
  ident: b7-mmr-12-03-4055
  article-title: Isolation of putative progenitor endothelial cells for angiogenesis
  publication-title: Science
  contributor:
    fullname: Sullivan
– volume: 131
  start-page: 562
  year: 2010
  end-page: 566
  ident: b10-mmr-12-03-4055
  article-title: Pro-angiogenic actions of Salvianolic acids on in vitro cultured endothelial progenitor cells and chick embryo chorioallantoic membrane model
  publication-title: J Ethnopharmacol
  contributor:
    fullname: Xu
– volume: 351
  start-page: 1425
  year: 2004
  end-page: 1436
  ident: b8-mmr-12-03-4055
  article-title: Treatment of pulmonary arterial hypertension
  publication-title: N Engl J Med
  contributor:
    fullname: Simonneau
– volume: 106
  start-page: 2700
  year: 2002
  end-page: 2706
  ident: b30-mmr-12-03-4055
  article-title: Anti-monocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice
  publication-title: Circulation
  contributor:
    fullname: Ni
– volume: 28
  start-page: 662
  year: 2012
  end-page: 666
  ident: b33-mmr-12-03-4055
  article-title: Inflammation and coronary artery disease: insights from genetic studies
  publication-title: Can J Cardiol
  contributor:
    fullname: Davies
– volume: 47
  start-page: 1836
  year: 2003
  end-page: 1841
  ident: b4-mmr-12-03-4055
  article-title: Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminogly-coside-induced free radical formation in vitro and ototoxicity in vivo
  publication-title: Antimicrob Agents Chemother
  contributor:
    fullname: Schacht
– volume: 128
  start-page: 350
  year: 2008
  end-page: 358
  ident: b6-mmr-12-03-4055
  article-title: Effects of four medicinal herbs on human vascular endothelial cells in culture
  publication-title: Int J Cardiol
  contributor:
    fullname: Komesaroff
– volume: 44
  start-page: 352
  year: 2011
  end-page: 359
  ident: b12-mmr-12-03-4055
  article-title: Effects of tumour necrosis factor-alpha on activity and nitric oxide synthase of endothelial progenitor cells from peripheral blood
  publication-title: Cell Prolif
  contributor:
    fullname: Zhao
– volume: 113
  start-page: 275
  year: 2009
  end-page: 280
  ident: b24-mmr-12-03-4055
  article-title: The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS
  publication-title: J Steroid Biochem Mol Biol
  contributor:
    fullname: Wang
– volume: 95
  start-page: 858
  year: 2004
  end-page: 866
  ident: b31-mmr-12-03-4055
  article-title: Chemokines in the pathogenesis of vascular disease
  publication-title: Circ Res
  contributor:
    fullname: Taubman
– volume: 9
  start-page: e100045
  year: 2014
  ident: b29-mmr-12-03-4055
  article-title: Inflammatory biomarkers in atherosclerosis: Pentraxin 3 can become a novel marker of plaque vulnerability
  publication-title: PLoS One
  contributor:
    fullname: Fujisawa
– volume: 115
  start-page: 217
  year: 2008
  end-page: 222
  ident: b35-mmr-12-03-4055
  article-title: Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit
  publication-title: J Ethnopharmacol
  contributor:
    fullname: Zhang
– volume: 568
  start-page: 213
  year: 2007
  end-page: 221
  ident: b5-mmr-12-03-4055
  article-title: Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis
  publication-title: Eur J Pharmacol
  contributor:
    fullname: Liu
– volume: 109
  start-page: 2826
  year: 2004
  end-page: 2831
  ident: b32-mmr-12-03-4055
  article-title: Janus phenomenon: the interrelated tradeoffs inherent in therapies designed to enhance collateral formation and those designed to inhibit atherogenesis
  publication-title: Circulation
  contributor:
    fullname: Burnett
– volume: 22
  start-page: 1325
  year: 2013
  end-page: 1336
  ident: b9-mmr-12-03-4055
  article-title: Endothelial progenitor cell-based therapy for pulmonary arterial hypertension
  publication-title: Cell Transplant
  contributor:
    fullname: Wang
– volume: 93
  start-page: e17
  year: 2003
  end-page: 24
  ident: b22-mmr-12-03-4055
  article-title: Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury
  publication-title: Circ Res
  contributor:
    fullname: Nickenig
– volume: 45
  start-page: 1345
  year: 2005
  end-page: 1359
  ident: b2-mmr-12-03-4055
  article-title: Danshen: an overview of its chemistry, pharmacology, pharmacokinetics and clinical use
  publication-title: J Clin Pharmacol
  contributor:
    fullname: Chow
– volume: 7
  start-page: e46511
  year: 2012
  ident: b14-mmr-12-03-4055
  article-title: Zoledronate attenuates angiogenic effects of angiotensin II-stimulated endothelial progenitor cells via RhoA and MAPK signaling
  publication-title: PLoS One
  contributor:
    fullname: Hu
– volume: 12
  start-page: 237
  year: 2005
  end-page: 246
  ident: b1-mmr-12-03-4055
  article-title: Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza
  publication-title: Curr Med Chem
  contributor:
    fullname: Fung
– volume: 21
  start-page: 207
  year: 2014
  end-page: 216
  ident: b25-mmr-12-03-4055
  article-title: The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-alpha-induced VCAM-1, ICAM-1 and CX3CL1 expression
  publication-title: Phytomedicine
  contributor:
    fullname: Huang
– volume: 108
  start-page: 217
  year: 2006
  end-page: 222
  ident: b34-mmr-12-03-4055
  article-title: Protective effect of tanshinone IIA on human umbilical vein endo-thelial cell injured by hydrogen peroxide and its mechanism
  publication-title: J Ethnopharmacol
  contributor:
    fullname: Han
– volume: 104
  start-page: 87
  year: 2009
  end-page: 92
  ident: b17-mmr-12-03-4055
  article-title: Down-regulation of CD40 gene expression and inhibition of apoptosis with Danshensu in endothelial cells
  publication-title: Basic Clin Pharmacol Toxicol
  contributor:
    fullname: Ji
– volume: 5
  start-page: 1641
  year: 2005
  end-page: 1651
  ident: b15-mmr-12-03-4055
  article-title: Aqueous extract of Salvia miltiorrhiza attenuates increased endothelial permeability induced by tumor necrosis factor-alpha
  publication-title: Int Immunopharmacol
  contributor:
    fullname: Guo
– volume: 12
  start-page: 251
  year: 2010
  end-page: 259
  ident: b13-mmr-12-03-4055
  article-title: Superparamagnetic iron oxide nanoparticles may affect endothelial progenitor cell migration ability and adhesion capacity
  publication-title: Cytotherapy
  contributor:
    fullname: Wang
– volume: 325
  start-page: 997
  year: 1991
  end-page: 1001
  ident: b18-mmr-12-03-4055
  article-title: Circulating and tissue endothelin immuno-reactivity in advanced atherosclerosis
  publication-title: N Engl J Med
  contributor:
    fullname: Burnett
– volume: 72
  start-page: 85
  year: 2014
  end-page: 94
  ident: b11-mmr-12-03-4055
  article-title: TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ. J Mol
  publication-title: Cell Cardiol
  contributor:
    fullname: Bian
– volume: 348
  start-page: 593
  year: 2003
  end-page: 600
  ident: b19-mmr-12-03-4055
  article-title: Circulating endothelial progenitor cells, vascular function and cardiovascular risk
  publication-title: N Engl J Med
  contributor:
    fullname: Finkel
– volume: 108
  start-page: 2710
  year: 2003
  end-page: 2715
  ident: b21-mmr-12-03-4055
  article-title: Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy
  publication-title: Circulation
  contributor:
    fullname: Melo
– volume: 105
  start-page: 1135
  year: 2002
  end-page: 1143
  ident: b28-mmr-12-03-4055
  article-title: Inflammation and atherosclerosis
  publication-title: Circulation
  contributor:
    fullname: Maseri
– volume: 340
  start-page: 115
  year: 1999
  end-page: 126
  ident: b16-mmr-12-03-4055
  article-title: Atherosclerosis - an inflammatory disease
  publication-title: N Engl J Med
  contributor:
    fullname: Ross
– volume: 11
  start-page: 618
  year: 2010
  end-page: 626
  ident: b23-mmr-12-03-4055
  article-title: Danshen protects endothelial progenitor cells from oxidized low-density lipoprotein induced impairment
  publication-title: J Zhejiang Univ Sci B
  contributor:
    fullname: Tang
– volume: 23
  start-page: 1163
  year: 2002
  end-page: 1168
  ident: b3-mmr-12-03-4055
  article-title: Contents of four active components in different commercial crude drugs and preparations of danshen (Salvia miltiorrhiza)
  publication-title: Acta Pharmacol Sin
  contributor:
    fullname: Zhu
– volume: 33
  start-page: 305
  year: 2000
  end-page: 312
  ident: b27-mmr-12-03-4055
  article-title: Tanshinone II-A inhibits low density lipoprotein oxidation in vitro
  publication-title: Free Radic Res
  contributor:
    fullname: Nakazawa
– volume: 18
  start-page: 3964
  year: 1999
  end-page: 3972
  ident: b20-mmr-12-03-4055
  article-title: VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
  publication-title: EMBO J
  contributor:
    fullname: Masuda
– volume: 93
  start-page: e17
  year: 2003
  ident: key20180108020330_b22-mmr-12-03-4055
  article-title: Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000083812.30141.74
  contributor:
    fullname: Werner
– volume: 115
  start-page: 217
  year: 2008
  ident: key20180108020330_b35-mmr-12-03-4055
  article-title: Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2007.09.025
  contributor:
    fullname: Fang
– volume: 7
  start-page: e46511
  year: 2012
  ident: key20180108020330_b14-mmr-12-03-4055
  article-title: Zoledronate attenuates angiogenic effects of angiotensin II-stimulated endothelial progenitor cells via RhoA and MAPK signaling
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0046511
  contributor:
    fullname: Yang
– volume: 22
  start-page: 1325
  year: 2013
  ident: key20180108020330_b9-mmr-12-03-4055
  article-title: Endothelial progenitor cell-based therapy for pulmonary arterial hypertension
  publication-title: Cell Transplant
  doi: 10.3727/096368912X659899
  contributor:
    fullname: Yang
– volume: 275
  start-page: 964
  year: 1997
  ident: key20180108020330_b7-mmr-12-03-4055
  article-title: Isolation of putative progenitor endothelial cells for angiogenesis
  publication-title: Science
  doi: 10.1126/science.275.5302.964
  contributor:
    fullname: Asahara
– volume: 108
  start-page: 217
  year: 2006
  ident: key20180108020330_b34-mmr-12-03-4055
  article-title: Protective effect of tanshinone IIA on human umbilical vein endo-thelial cell injured by hydrogen peroxide and its mechanism
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2006.05.004
  contributor:
    fullname: Lin
– volume: 104
  start-page: 87
  year: 2009
  ident: key20180108020330_b17-mmr-12-03-4055
  article-title: Down-regulation of CD40 gene expression and inhibition of apoptosis with Danshensu in endothelial cells
  publication-title: Basic Clin Pharmacol Toxicol
  doi: 10.1111/j.1742-7843.2008.00342.x
  contributor:
    fullname: Yang
– volume: 47
  start-page: 1836
  year: 2003
  ident: key20180108020330_b4-mmr-12-03-4055
  article-title: Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminogly-coside-induced free radical formation in vitro and ototoxicity in vivo
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.47.6.1836-1841.2003
  contributor:
    fullname: Wang
– volume: 28
  start-page: 662
  year: 2012
  ident: key20180108020330_b33-mmr-12-03-4055
  article-title: Inflammation and coronary artery disease: insights from genetic studies
  publication-title: Can J Cardiol
  doi: 10.1016/j.cjca.2012.05.014
  contributor:
    fullname: McPherson
– volume: 12
  start-page: 251
  year: 2010
  ident: key20180108020330_b13-mmr-12-03-4055
  article-title: Superparamagnetic iron oxide nanoparticles may affect endothelial progenitor cell migration ability and adhesion capacity
  publication-title: Cytotherapy
  doi: 10.3109/14653240903446910
  contributor:
    fullname: Yang
– volume: 11
  start-page: 618
  year: 2010
  ident: key20180108020330_b23-mmr-12-03-4055
  article-title: Danshen protects endothelial progenitor cells from oxidized low-density lipoprotein induced impairment
  publication-title: J Zhejiang Univ Sci B
  doi: 10.1631/jzus.B1001008
  contributor:
    fullname: Ji
– volume: 12
  start-page: 237
  year: 2005
  ident: key20180108020330_b1-mmr-12-03-4055
  article-title: Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza
  publication-title: Curr Med Chem
  doi: 10.2174/0929867053363397
  contributor:
    fullname: Jiang
– volume: 109
  start-page: 2826
  year: 2004
  ident: key20180108020330_b32-mmr-12-03-4055
  article-title: Janus phenomenon: the interrelated tradeoffs inherent in therapies designed to enhance collateral formation and those designed to inhibit atherogenesis
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000132468.82942.F5
  contributor:
    fullname: Epstein
– volume: 5
  start-page: 1641
  year: 2005
  ident: key20180108020330_b15-mmr-12-03-4055
  article-title: Aqueous extract of Salvia miltiorrhiza attenuates increased endothelial permeability induced by tumor necrosis factor-alpha
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2005.05.005
  contributor:
    fullname: Ding
– volume: 18
  start-page: 3964
  year: 1999
  ident: key20180108020330_b20-mmr-12-03-4055
  article-title: VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
  publication-title: EMBO J
  doi: 10.1093/emboj/18.14.3964
  contributor:
    fullname: Asahara
– volume: 45
  start-page: 1345
  year: 2005
  ident: key20180108020330_b2-mmr-12-03-4055
  article-title: Danshen: an overview of its chemistry, pharmacology, pharmacokinetics and clinical use
  publication-title: J Clin Pharmacol
  doi: 10.1177/0091270005282630
  contributor:
    fullname: Zhou
– volume: 9
  start-page: e100045
  year: 2014
  ident: key20180108020330_b29-mmr-12-03-4055
  article-title: Inflammatory biomarkers in atherosclerosis: Pentraxin 3 can become a novel marker of plaque vulnerability
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0100045
  contributor:
    fullname: Shindo
– volume: 105
  start-page: 1135
  year: 2002
  ident: key20180108020330_b28-mmr-12-03-4055
  article-title: Inflammation and atherosclerosis
  publication-title: Circulation
  doi: 10.1161/hc0902.104353
  contributor:
    fullname: Libby
– volume: 340
  start-page: 115
  year: 1999
  ident: key20180108020330_b16-mmr-12-03-4055
  article-title: Atherosclerosis - an inflammatory disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199901143400207
  contributor:
    fullname: Ross
– volume: 106
  start-page: 2700
  year: 2002
  ident: key20180108020330_b30-mmr-12-03-4055
  article-title: Anti-monocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000038140.80105.AD
  contributor:
    fullname: Inoue
– volume: 72
  start-page: 85
  year: 2014
  ident: key20180108020330_b11-mmr-12-03-4055
  article-title: TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ. J Mol
  publication-title: Cell Cardiol
  doi: 10.1016/j.yjmcc.2014.02.012
  contributor:
    fullname: Zhang
– volume: 568
  start-page: 213
  year: 2007
  ident: key20180108020330_b5-mmr-12-03-4055
  article-title: Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2007.04.031
  contributor:
    fullname: Fu
– volume: 21
  start-page: 207
  year: 2014
  ident: key20180108020330_b25-mmr-12-03-4055
  article-title: The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-alpha-induced VCAM-1, ICAM-1 and CX3CL1 expression
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2013.09.012
  contributor:
    fullname: Chang
– volume: 44
  start-page: 352
  year: 2011
  ident: key20180108020330_b12-mmr-12-03-4055
  article-title: Effects of tumour necrosis factor-alpha on activity and nitric oxide synthase of endothelial progenitor cells from peripheral blood
  publication-title: Cell Prolif
  doi: 10.1111/j.1365-2184.2011.00764.x
  contributor:
    fullname: Chen
– volume: 348
  start-page: 593
  year: 2003
  ident: key20180108020330_b19-mmr-12-03-4055
  article-title: Circulating endothelial progenitor cells, vascular function and cardiovascular risk
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa022287
  contributor:
    fullname: Hill
– volume: 33
  start-page: 305
  year: 2000
  ident: key20180108020330_b27-mmr-12-03-4055
  article-title: Tanshinone II-A inhibits low density lipoprotein oxidation in vitro
  publication-title: Free Radic Res
  doi: 10.1080/10715760000301471
  contributor:
    fullname: Niu
– volume: 128
  start-page: 350
  year: 2008
  ident: key20180108020330_b6-mmr-12-03-4055
  article-title: Effects of four medicinal herbs on human vascular endothelial cells in culture
  publication-title: Int J Cardiol
  doi: 10.1016/j.ijcard.2007.05.111
  contributor:
    fullname: Ling
– volume: 131
  start-page: 562
  year: 2010
  ident: key20180108020330_b10-mmr-12-03-4055
  article-title: Pro-angiogenic actions of Salvianolic acids on in vitro cultured endothelial progenitor cells and chick embryo chorioallantoic membrane model
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2010.07.040
  contributor:
    fullname: Li
– volume: 19
  start-page: 47
  year: 1998
  ident: key20180108020330_b26-mmr-12-03-4055
  article-title: Effects of tanshinone II-A sulfonate on adhesion molecule expression of endothelial cells and platelets in vitro
  publication-title: Acta Pharmacol Sin
  contributor:
    fullname: Jiang
– volume: 23
  start-page: 1163
  year: 2002
  ident: key20180108020330_b3-mmr-12-03-4055
  article-title: Contents of four active components in different commercial crude drugs and preparations of danshen (Salvia miltiorrhiza)
  publication-title: Acta Pharmacol Sin
  contributor:
    fullname: Zhang
– volume: 113
  start-page: 275
  year: 2009
  ident: key20180108020330_b24-mmr-12-03-4055
  article-title: The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2009.01.011
  contributor:
    fullname: Fan
– volume: 95
  start-page: 858
  year: 2004
  ident: key20180108020330_b31-mmr-12-03-4055
  article-title: Chemokines in the pathogenesis of vascular disease
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000146672.10582.17
  contributor:
    fullname: Charo
– volume: 351
  start-page: 1425
  year: 2004
  ident: key20180108020330_b8-mmr-12-03-4055
  article-title: Treatment of pulmonary arterial hypertension
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra040291
  contributor:
    fullname: Humbert
– volume: 325
  start-page: 997
  year: 1991
  ident: key20180108020330_b18-mmr-12-03-4055
  article-title: Circulating and tissue endothelin immuno-reactivity in advanced atherosclerosis
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199110033251404
  contributor:
    fullname: Lerman
– volume: 108
  start-page: 2710
  year: 2003
  ident: key20180108020330_b21-mmr-12-03-4055
  article-title: Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000096490.16596.A6
  contributor:
    fullname: Griese
SSID ssj0065259
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Snippet Tanshinone IIA (Tan IIA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular...
Tanshinone ⅡA (Tan ⅡA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular...
Tanshinone HA (Tan HA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention and treatment of cardiovascular...
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Index Database
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StartPage 4055
SubjectTerms Animals
Arteriosclerosis
Atherosclerosis
Care and treatment
CD40 antigen
CD40 Ligand - metabolism
Cell Adhesion - drug effects
Cell Movement - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Chemokine CCL2 - metabolism
Chinese medicine
Development and progression
Diterpenes, Abietane - pharmacology
endothelial progenitor cell
Endothelial Progenitor Cells - cytology
Endothelial Progenitor Cells - drug effects
Endothelial Progenitor Cells - metabolism
Epidermal growth factor
Health aspects
Inflammation
Interleukin 6
Interleukin-6 - metabolism
Leukocyte migration
Male
Medicine, Chinese
Medicine, Chinese Traditional
Microscopy, Fluorescence
migration
Monocyte chemoattractant protein
Monocyte chemoattractant protein 1
Necrosis
paracrine
Paracrine signalling
Protective Agents - pharmacology
Rats
Rats, Sprague-Dawley
Rodents
Stem cells
Studies
tanshinone IIA
Traditional Chinese medicine
Tumor necrosis factor
Tumor Necrosis Factor-alpha - toxicity
Tumor necrosis factor-TNF
Tumor necrosis factor-α
vasculogenesis
Title Protective effects of tanshinone IIA on endothelial progenitor cells injured by tumor necrosis factor-α
URI https://www.ncbi.nlm.nih.gov/pubmed/26095681
https://www.proquest.com/docview/1932471766
https://search.proquest.com/docview/1697214342
https://pubmed.ncbi.nlm.nih.gov/PMC4526031
Volume 12
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