Differences in Red Blood Cell Indices Do Not Explain Racial Disparity in Hemoglobin A1c in Children with Type 1 Diabetes

We assessed the association of erythrocyte indices on mean blood glucose-independent racial disparity in hemoglobin A1c (HbA1c) in youth with type 1 diabetes. Blacks still had higher HbA1c after adjustment for mean blood glucose, red blood cell indices, age, and sex. Such differences need to be take...

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Published inThe Journal of pediatrics Vol. 176; pp. 197 - 199
Main Authors Hamdan, Mahmoud Adeeb Ahmad, MD, Hempe, James M., PhD, Velasco-Gonzalez, Cruz, PhD, Gomez, Ricardo, MD, Vargas, Alfonso, MD, Chalew, Stuart, MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2016
Subjects
Adolescent
African Americans
biological variation
Child
Diabetes Mellitus, Type 1 - blood
Erythrocyte Indices
European Continental Ancestry Group
Female
Glycated Hemoglobin A - analysis
Humans
lab interpretation
Male
mean blood glucose
Pediatrics
MCV
Mean corpuscular hemoglobin
Mean corpuscular volume
CBC
T1D
Red blood cell
RDW-CV
RDW-SD
Complete blood count
lab interpretation
RBC
MBG
MCH
biological variation
Hemoglobin A1c
Red cell distribution width coefficient of variation
Type 1 diabetes
Red cell distribution width SD
WBC
mean blood glucose
HbA1c
White blood cell
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Summary:We assessed the association of erythrocyte indices on mean blood glucose-independent racial disparity in hemoglobin A1c (HbA1c) in youth with type 1 diabetes. Blacks still had higher HbA1c after adjustment for mean blood glucose, red blood cell indices, age, and sex. Such differences need to be taken into account when interpreting HbA1c in Black patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2016.03.068