Cell-based therapy in the management of Class III Miller's recession - A case report with 45-month follow-up

• Published in: Journal of Indian Society of Periodontology Vol. 27; no. 4; pp. 437 - 442
• Main Authors: Meenakshi, R, Kiruba, R, Arun, K, Sivaram, G, Arumuganainar, Deepavalli, Kaveri, K
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01.07.2023; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: autologous fibroblasts; Case Report; Case reports; cell-based therapy; Collagen; collagen membrane; Fibroblasts; miller's class iii recession; recession type 2; Recessions; root coverage; root coverage; Miller's Class III recession; Autologous fibroblasts; cell-based therapy; recession Type 2; collagen membrane
• ISSN: 0972-124X; 0975-1580
• DOI: 10.4103/jisp.jisp_436_22

Miller's Class III gingival recessions (GRs) have always posed a challenge to the clinicians in terms of achieving complete root coverage (CRC). In the present case, a cell-based therapy with autologous fibroblasts seeded onto a Type 1 collagen membrane, through an in-vitro culturing method was utilized. The fibroblasts-seeded membrane was surgically placed under a laterally repositioned flap. The patient presented with a CRC, which was stable even at the postoperative period of 45 months. In addition, a 3-mm substantial gain in the width of keratinized tissue was achieved and maintained throughout the postoperative period. Hence, the results of the cell-seeded therapy emphasize that it can serve as an effective alternative method for the management of Miller's Class III GRs.