Emergence of taurine as a therapeutic agent for neurological disorders

• Published in: Neural regeneration research Vol. 19; no. 1
• Main Authors: Jangra, Ashok, Gola, Priyanka, Singh, Jiten, Gond, Pooja, Ghosh, Swarnabha, Rachamalla, Mahesh, Dey, Abhijit, Iqbal, Danish, Kamal, Mehnaz, Sachdeva, Punya, Jha, Saurabh, Ojha, Shreesh, Kumar, Dinesh, Jha, Niraj, Chopra, Hitesh, Tan, Shing
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.01.2024; Medknow Publications & Media Pvt. Ltd; Department of Pharmaceutical Sciences,Central University of Haryana,Mahendergarh,Haryana,India%Department of Biology,University of Saskatchewan,Saskatoon,SK,Canada%Department of Life Sciences,Presidency University,Kolkata,West Bengal,India%Department of Health Information Management,College of Applied Medical Sciences,Buraydah Private Colleges,Buraydah,Saudi Arabia%Department of Pharmaceutical Chemistry,College of Pharmacy,Prince Sattam Bin Abdulaziz University,Al-Kharj,Saudi Arabia%GloNeuro,Vishwakarma Road,Noida,India%Department of Biotechnology,School of Engineering & Technology(SET),Sharda University,Greater Noida,Uttar Pradesh,India%Department of Pharmacology and Therapeutics,College of Medicine and Health Sciences,United Arab Emirates University,Al Ain,United Arab Emirates%Department of Biotechnology,School of Engineering & Technology(SET),Sharda University,Greater Noida,Uttar Pradesh,India; Department of Biotechnology,School of Applied & Life Sciences(SALS),Uttaranchal University,Dehradun,India%Chitkara College of Pharmacy,Chitkara University,Punjab,India%UKM Medical Molecular Biology Institute,Universiti Kebangsaan Malaysia,Kuala Lumpur,Malaysia; School of Bioengineering & Biosciences,Lovely Professional University,Phagwara,India; Wolters Kluwer - Medknow
• Subjects: Neurological disorders; Review; epilepsy; spinal cord injury; antioxidant; neuroprotection; taurine; neurodegenerative disorders; oxidative stress; γ-amino butyric acid; y-amino butyric acid
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.374139

Taurine is a sulfur-containing, semi-essential amino acid that occurs naturally in the body. It alternates between inflammation and oxidative stress-mediated injury in various disease models. As part of its limiting functions, taurine also modulates endoplasmic reticulum stress, Ca homeostasis, and neuronal activity at the molecular level. Taurine effectively protects against a number of neurological disorders, including stroke, epilepsy, cerebral ischemia, memory dysfunction, and spinal cord injury. Although various therapies are available, effective management of these disorders remains a global challenge. Approximately 30 million people are affected worldwide. The design of taurine formation could lead to potential drugs/supplements for the health maintenance and treatment of central nervous system disorders. The general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this review. This article is a good resource for understanding the general effects of taurine on various diseases. Given the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms, it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics, with emphasis on mechanism and clinical studies to determine efficacy.