Physical exosome:exosome interactions

Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome–exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact wi...

Full description

Saved in:
Bibliographic Details
Published inJournal of cellular and molecular medicine Vol. 22; no. 3; pp. 2001 - 2006
Main Authors Beit‐Yannai, Elie, Tabak, Saray, Stamer, W. Daniel
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.03.2018
John Wiley and Sons Inc
Subjects
exosome
Exosomes
hypothesis
Intracellular signalling
physical interaction
Short Communication
Short Communications
signalling
zeta potential
zeta potential
physical interaction
exosome
hypothesis
signalling
Online AccessGet full text

Cover

More Information
Summary:Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome–exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome‐mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.13479