Photopatterning of multifunctional hydrogels to direct adult neural precursor cells

Matrix-metalloproteinase and photosensitive peptide units are combined with heparin and poly(ethylene glycol) into a light-sensitive multicomponent hydrogel material. Localized degradation of the hydrogel matrix allows the creation of defined spatial constraints and adhesive patterning for cells gro...

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Published inAdvanced healthcare materials Vol. 4; no. 4; p. 516
Main Authors Tsurkan, Mikhail V, Wetzel, Richard, Pérez-Hernández, Heidi R, Chwalek, Karolina, Kozlova, Anna, Freudenberg, Uwe, Kempermann, Gerd, Zhang, Yixin, Lasagni, Andrés F, Werner, Carsten
Format Journal Article
LanguageEnglish
Published Germany 01.03.2015
Subjects
Adult Stem Cells - cytology
Adult Stem Cells - drug effects
Animals
Cell Proliferation - drug effects
Glass - chemistry
Heparin - chemistry
Hydrogels - pharmacology
Light
Mice
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
multilayer surfaces
photopatterning
biohybrid hydrogels
neural precursor cells
photocleavable soft matter
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Summary:Matrix-metalloproteinase and photosensitive peptide units are combined with heparin and poly(ethylene glycol) into a light-sensitive multicomponent hydrogel material. Localized degradation of the hydrogel matrix allows the creation of defined spatial constraints and adhesive patterning for cells grown in culture. Using this matrix system, it is demonstrated that the degree of confinement determines the fate of neural precursor cells in vitro.
ISSN:2192-2659
DOI:10.1002/adhm.201400395