Emerging role of Twist1 in fibrotic diseases

Epithelial–mesenchymal transition (EMT) is a pathological process that occurs in a variety of diseases, including organ fibrosis. Twist1, a basic helix–loop–helix transcription factor, is involved in EMT and plays significant roles in various fibrotic diseases. Suppression of the EMT process represe...

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Published inJournal of cellular and molecular medicine Vol. 22; no. 3; pp. 1383 - 1391
Main Authors Ning, Xiaoxuan, Zhang, Kun, Wu, Qingfeng, Liu, Minna, Sun, Shiren
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.03.2018
John Wiley and Sons Inc
Subjects
Diseases
epithelial–mesenchymal transition
Fibrosis
fibrotic diseases
Lungs
Medical treatment
Mesenchyme
Molecular modelling
Pathogenesis
Review
Reviews
Tissues
Twist1
fibrotic diseases
epithelial-mesenchymal transition
Twist1
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Summary:Epithelial–mesenchymal transition (EMT) is a pathological process that occurs in a variety of diseases, including organ fibrosis. Twist1, a basic helix–loop–helix transcription factor, is involved in EMT and plays significant roles in various fibrotic diseases. Suppression of the EMT process represents a promising approach for the treatment of fibrotic diseases. In this review, we discuss the roles and the underlying molecular mechanisms of Twist1 in fibrotic diseases, including those affecting kidney, lung, skin, oral submucosa and other tissues. We aim at providing new insight into the pathogenesis of various fibrotic diseases and facilitating the development of novel diagnostic and therapeutic methods for their treatment.
Bibliography:ObjectType-Article-2
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These authors contributed equally to this work.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.13465