A trial of proficiency of nerve conduction: Greater standardization still needed

• Published in: Muscle & nerve Vol. 48; no. 3; pp. 369 - 374
• Main Authors: Dyck, Peter J., Albers, James W., Wolfe, James, Bolton, Charles F., Walsh, Nancy, Klein, Christopher J., Zafft, Andrew J., Russell, James W., Thomas, Karen, Davies, Jenny L., Carter, Rickey E., Melton III, L. Joseph, Litchy, William J.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2013; Wiley Subscription Services, Inc
• Subjects: Action Potentials - physiology; clinical trial; Diabetes; Diabetes Mellitus - diagnosis; Diabetes Mellitus - physiopathology; diabetic sensorimotor polyneuropathy; Electrodiagnosis - methods; Electrodiagnosis - standards; Humans; Judgment; nerve conduction; Neural Conduction - physiology; proficiency; Reaction Time - physiology; Reference Standards; standard reference value; Standardization; Time Factors; clinical trial; standard reference value; diabetic sensorimotor polyneuropathy; nerve conduction; proficiency
• ISSN: 0148-639X; 1097-4598
• DOI: 10.1002/mus.23765

ABSTRACT Introduction The aim of this study was to test the proficiency (accuracy among evaluators) of measured attributes of nerve conduction (NC). Methods Expert clinical neurophysiologists, without instruction or consensus development, from 4 different medical centers, independently assessed 8 attributes of NC in 24 patients with diabetes mellitus (DM) on consecutive days. Results No significant intraobserver differences between days 1 and 2 were found, but significant interobserver differences were seen. Use of standard reference values did not correct for these observed differences. Conclusions Interobserver variability was attributed to differences in performance of NC. It was of sufficient magnitude that it is of concern for the conduct of therapeutic trials. To deal with interrater variability in therapeutic trials, the same electromyographers should perform all NC assessments of individual patients or, preferably, NC procedures should be more standardized. A further trial is needed to test whether such standardization would eliminate interobserver variability. Muscle Nerve 48: 369–374, 2013