Mitochondrial biogenesis: An update

• Published in: Journal of cellular and molecular medicine Vol. 24; no. 9; pp. 4892 - 4899
• Main Author: Popov, Lucia‐Doina
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2020; John Wiley and Sons Inc
• Subjects: ageing; Aging; Biosynthesis; cancer; Gene expression; Genomes; Homeostasis; Kinases; metabolic diseases; Metabolic disorders; Mitochondria; Mitochondrial DNA; mtDNA; Neurodegeneration; nuclear respiratory factors; Oxidative stress; PGC‐1α; Phosphorylation; Proteins; Regeneration; Review; Reviews; Signal transduction; Therapeutic applications; transcription factor A; Transcription factors; transcription factor A; ageing; metabolic diseases; mtDNA; neurodegeneration; PGC-1α; cancer; nuclear respiratory factors
• ISSN: 1582-1838; 1582-4934; 1582-4934
• DOI: 10.1111/jcmm.15194

In response to the energy demand triggered by developmental signals and environmental stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal route, by which new mitochondria are generated from the ones already existing. Recently, considerable progress has been made...