miR‐451a inhibits cancer growth, epithelial‐mesenchymal transition and induces apoptosis in papillary thyroid cancer by targeting PSMB8

Despite the increasing incidence of papillary thyroid cancer in the past decade, the molecular mechanism underlying its progression remains unknown. Several studies have reported down‐regulation of miR‐451a or circular miR‐451a in papillary thyroid cancer cell lines or patients. However, the underly...

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Bibliographic Details
Published inJournal of cellular and molecular medicine Vol. 23; no. 12; pp. 8067 - 8075
Main Authors Fan, Xinlong, Zhao, Yuejiao
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.12.2019
John Wiley and Sons Inc
Subjects
Animals
Apoptosis
Apoptosis - genetics
Biomarkers
Cell growth
Cell Line, Tumor
Cell Movement - genetics
Cell proliferation
Cell Proliferation - genetics
Disease Progression
Epithelial-Mesenchymal Transition - genetics
Ethics
Experiments
Gene Expression Regulation, Neoplastic - genetics
Humans
Lung cancer
Lymphatic system
Medical prognosis
Mesenchyme
Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNAs
miR‐451a
Original
Papillary thyroid cancer
Proteasome Endopeptidase Complex - genetics
Proteasome Endopeptidase Complex - metabolism
Proteasomes
Proteins
PSMB8
RNA, Small Interfering
Studies
Thyroid cancer
Thyroid Cancer, Papillary - genetics
Thyroid Cancer, Papillary - metabolism
Transplantation, Heterologous
Tumor cell lines
miRNAs
miR-451a
papillary thyroid cancer
PSMB8
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Summary:Despite the increasing incidence of papillary thyroid cancer in the past decade, the molecular mechanism underlying its progression remains unknown. Several studies have reported down‐regulation of miR‐451a or circular miR‐451a in papillary thyroid cancer cell lines or patients. However, the underlying molecular mechanism remains unknown. In this study, we found that overexpression of miR‐451a could inhibit proliferation, epithelial‐mesenchymal transition and induce apoptosis in papillary thyroid cancer cells. Proteasome subunit beta type‐8 was predicted to be a direct target of miR‐451a and was validated with a luciferase reporter assay. Further functional assays showed that miR‐451a could inhibit thyroid cancer progression by targeting proteasome subunit beta type‐8.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.14673