Behavior in dogs with spontaneous hypothyroidism during treatment with levothyroxine

• Published in: Journal of veterinary internal medicine Vol. 33; no. 1; pp. 64 - 71
• Main Authors: Hrovat, Alenka, De Keuster, Tiny, Kooistra, Hans S., Duchateau, Luc, Oyama, Mark A., Peremans, Kathelijne, Daminet, Sylvie
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2019; Wiley
• Subjects: Aggression - drug effects; Animal behavior; Animals; Behavior, Animal - drug effects; canine; Clinical trials; Dog Diseases - drug therapy; Dog Diseases - psychology; Dogs; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - veterinary; Female; Hypothyroidism; Hypothyroidism - drug therapy; Hypothyroidism - veterinary; Male; Prolactin; Prolactin - blood; Prospective Studies; Radioimmunoassay; Serotonin; Serotonin - blood; SMALL ANIMAL; Thyroid; Thyroid gland; thyroid supplementation; Thyroxine; Thyroxine - therapeutic use; serotonin; canine; prolactin; thyroid supplementation
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/jvim.15342

Background Thyroid hormone supplementation anecdotally has been described as a valid treatment option for dogs with aggression‐related problems. However, prospective, controlled, and blinded trials evaluating behavior and neurohormonal status in hypothyroid dogs during treatment with levothyroxine are lacking. Objective Levothyroxine supplementation will have a significant influence on the behavior and neurohormonal status of dogs with spontaneous hypothyroidism. Animals Twenty client‐owned dogs diagnosed with spontaneous hypothyroidism. Methods This prospective study was to evaluate the behavior of dogs, which was screened at initial presentation, and after 6 weeks, and 6 months of treatment with levothyroxine (starting dosage 10 μg/kg PO q12h) using the standardized Canine Behavioral Assessment and Research Questionnaire (C‐BARQ). At each time period, circulating serotonin and prolactin (PRL) concentrations were evaluated using a commercially validated ELISA kit and heterologous radioimmunoassay, respectively. Results After 6 weeks of thyroid hormone supplementation, C‐BARQ scores demonstrated a significant increase in activity of hypothyroid dogs (P < .01). No significant change in any of the behavioral signs was observed after 6 months of treatment. No significant difference in circulating concentrations of serotonin (P > .99 and P = .46) and PRL (P = .99 and P = .37) were noted between the 6‐week and 6‐month periods compared with baseline. Conclusions and Clinical Importance The results of this study indicate increased activity of hypothyroid dogs after 6 weeks of thyroid hormone supplementation. None of the hypothyroid dogs in this cohort showed a significant change in any of the evaluated behavioral signs and neurohormonal status after 6 months of thyroid hormone supplementation.