Cysteine-Selective Reactions for Antibody Conjugation

Moving tracks from maleimide: New site‐selective protein modification reactions at cysteine have been developed. Unlike conventional maleimide conjugation, which results in a labile thioether succinimide, the new bioconjugation reactions result in stable conjugates and provide opportunities to devel...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 53; no. 40; pp. 10585 - 10587
Main Authors Cal, Pedro M. S. D., Bernardes, Gonçalo J. L., Gois, Pedro M. P.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 26.09.2014
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Antibodies
bioorganic chemistry
Conjugates
Conjugation
Cysteine
Cysteine - chemistry
drug delivery
Humans
maleimides
Oxadiazoles - chemistry
Proteins
Proteins - chemistry
Succinimides
Sulfhydryl Compounds - chemistry
antibodies
drug delivery
conjugation
bioorganic chemistry
maleimides
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Summary:Moving tracks from maleimide: New site‐selective protein modification reactions at cysteine have been developed. Unlike conventional maleimide conjugation, which results in a labile thioether succinimide, the new bioconjugation reactions result in stable conjugates and provide opportunities to develop a new generation of homogeneous, stable, and therapeutically useful conjugates.
Bibliography:ArticleID:ANIE201405702
P.M.S.D.C. and P.M.P.G. thank FCT (PTDC/QUI-QUI/118315/2010, Pest-OE/SAU/UI4013/2011, SFRH/BD/72376/2010) for financial support. G.J.L.B. is a Royal Society University Research Fellow and an FCT Investigator.
FCT - No. PTDC/QUI-QUI/118315/2010; No. Pest-OE/SAU/UI4013/2011; No. SFRH/BD/72376/2010
istex:748A53E9BAF3CD2EFEDD5DE802395BA242058EF4
ark:/67375/WNG-V48P96ZK-8
P.M.S.D.C. and P.M.P.G. thank FCT (PTDC/QUI‐QUI/118315/2010, Pest‐OE/SAU/UI4013/2011, SFRH/BD/72376/2010) for financial support. G.J.L.B. is a Royal Society University Research Fellow and an FCT Investigator.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201405702