Phosphatidylinositol 5-phosphate: A nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics
Phosphatidylinositol 5‐phosphate (PtdIns5P), the least characterized among the three phosphatidylinositol monophosphates, is emerging as a bioactive lipid involved in the control of several cellular functions. Similar to PtdIns3P, it is present in low amounts in mammalian cells, and can be detected...
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Published in | BioEssays Vol. 36; no. 3; pp. 260 - 272 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.03.2014
Wiley Subscription Services, Inc Wiley-VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | Phosphatidylinositol 5‐phosphate (PtdIns5P), the least characterized among the three phosphatidylinositol monophosphates, is emerging as a bioactive lipid involved in the control of several cellular functions. Similar to PtdIns3P, it is present in low amounts in mammalian cells, and can be detected at the plasma membrane and endomembranes as well as in the nucleus. Changes in PtdIns5P levels are observed in mammalian cells following specific stimuli or stresses, and in human diseases. Recently, the contribution of several enzymes such as PIKfyve, myotubularins, and type II PtdInsP‐kinases to PtdIns5P metabolism has gained a strong experimental support. Here, we provide a picture emerging from recent studies showing how this lipid can be generated and act as a regulator of membrane and cytoskeleton dynamics, and as a modulator of gene expression. We briefly summarize the current methods and tools for studying PtdIns5P, and discuss how PtdIns5P can integrate and coordinate different functions in a spatiotemporal manner.
Phosphatidylinositol 5‐phosphate (PtdIns5P), through the dynamic localization of lipid kinases and phosphatases, can be found in distinct sub‐cellular compartments. PtdIns5P recruits effector proteins mediating specific cellular functions such as trafficking, cytoskeleton and membrane dynamics, and intranuclear processes. |
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Bibliography: | ArticleID:BIES201300132 istex:5B8C165AFAE390B7080AEFCBF3A48AB9A6F8A2BC Inserm, Fondation ARC pour la Recherche contre le Cancer, Association Française contre les Myopathies, Fondation pour la Recherche Médicale, Association Lefoulon-Delalande, ANR 2010 MIDI 00703, ANR 2013 PI5PACTION ark:/67375/WNG-3X689Q7K-W ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0265-9247 1521-1878 |
DOI: | 10.1002/bies.201300132 |