Injectable Microbeads with a Thermo-Responsive Shell and a pH-Responsive Core as a Dual-Switch-Controlled Release System

Treating inflammation with a dual‐switch‐controlled release system: The release of a drug from the developed microbead system occurs only in response to both an increase in local temperature and an acidic environmental pH. This dual‐switch‐controlled release system has the advantages of distinguishi...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 10; no. 20; pp. 4100 - 4105
Main Authors Chiang, Wei-Lun, Hu, Yi-Chen, Liu, Hung-Yi, Hsiao, Chun-Wen, Sureshbabu, Radhakrishnan, Yang, Chih-Man, Chung, Min-Fan, Chia, Wei-Tso, Sung, Hsing-Wen
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 29.10.2014
Wiley Subscription Services, Inc
Subjects
controlled release
drug delivery
Drug Delivery Systems
Drugs
Effectiveness
Hydrogen-Ion Concentration
inflammatory diseases
Microscopy, Confocal
Microscopy, Electron, Scanning
Microspheres
Nanoparticles
Nanotechnology
Shells
smart carriers
stimuli-responsive materials
inflammatory diseases
controlled release
smart carriers
stimuli-responsive materials
drug delivery
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Summary:Treating inflammation with a dual‐switch‐controlled release system: The release of a drug from the developed microbead system occurs only in response to both an increase in local temperature and an acidic environmental pH. This dual‐switch‐controlled release system has the advantages of distinguishing between inflamed and healthy tissues to improve treatment efficacy.
Bibliography:National Science Council - No. 101-2120-M-007-015-CC1
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ArticleID:SMLL201400842
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201400842