Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network

The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermines the potential impact of QSP in academic, indust...

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Published inCPT: pharmacometrics and systems pharmacology Vol. 8; no. 5; pp. 259 - 272
Main Authors Cucurull‐Sanchez, Lourdes, Chappell, Michael J., Chelliah, Vijayalakshmi, Amy Cheung, S. Y., Derks, Gianne, Penney, Mark, Phipps, Alex, Malik‐Sheriff, Rahuman S., Timmis, Jon, Tindall, Marcus J., Graaf, Piet H., Vicini, Paolo, Yates, James W. T.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.05.2019
John Wiley and Sons Inc
Wiley
Subjects
Biology
Clinical trials
Councils
Drug dosages
Funding
Homeostasis
Language
Pediatrics
Pharmacology
R&D
Research & development
Stockholders
White Paper
United Kingdom > UK
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Summary:The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermines the potential impact of QSP in academic, industrial, and regulatory frameworks. This article presents a minimum set of recommendations from the UK Quantitative and Systems Pharmacology Network (UK QSP Network) to guide QSP practitioners seeking to maximize their impact, and stakeholders considering the use of QSP models in their environment.
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ISSN:2163-8306
2163-8306
DOI:10.1002/psp4.12381